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VEGF Growth Factors Are Markers For Metastasis And Survival.(vascular endothelial growth factor)(endometrial cancer)
2001 MAR 15 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer -- Scientists in Japan say two major angiogenic growth factors are predictive of invasive cancer, lymph node involvement, and disease-free survival in women with endometrial carcinoma.
Two forms of vascular endothelial growth factor (VEGF), VEGF-A/VEGF-1 and VEGF-C/VEGF-2, are differentially expressed by endometrial cancer cells, according to researchers at the Chiba Cancer Research Institute in Japan.
Their report described the results of an analysis of 228 cases of women with postmenopausal, endometrial carcinomas. In the analysis, researchers studied the depth of cancer invasion within the uterus, the extent of cancer spread to the lymph nodes and vessels, and the five-year and 10-year disease-free survival rate.
Those factors were compared to the amount of expression of the two growth factors in samples of the women's endometrial cancers obtained during surgery ("Expression of vascular endothelial growth factors (VEGF-A/VEGF-1 and VEGF-C/VEGF-2) in postmenopausal uterine endometrial carcinoma," Gynecologic Oncology, 2001;80(2):181-188).
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