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Study Reveals Mechanism Of Non-Hereditary Breast And Ovarian Cancers.(hypermethylation of the BRCA1 gene inhibits gene expression, causing breast and ovarian cancer)
2001 MAR 15 - (NewsRx.com & NewsRx.net) -- A new study has provided unexpected new evidence of a mechanism for non-hereditary breast and ovarian cancer.
Researchers found the hypermethylation of the BRCA1 gene was found to "turn off" gene expression and resulted in a breast cancer tumor. Collaborating scientists at the U.S. National Institutes of Health and Johns Hopkins Oncology Center, Johns Hopkins University, published their findings in the February 22, 2001, issue of the New England Journal of Medicine.
The international pharmacogenomics group Virco holds the patent on the diagnostic use of methylation and is working on the development of tests based on this process for use in a number of cancers.
The study was set up to investigate the mutations in the gene BRCA1 that can "switch-off" its tumor suppression effects, commonly leading to the development of cancer. These mutations can be inherited and cause "familial cancer." In the study, researchers unexpectedly discovered one breast cancer tumor typically ...
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Source: HighBeam Research, Study Reveals Mechanism Of Non-Hereditary Breast And Ovarian...