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Possible Drug-Gene Interaction Associated With Heart Attacks In Hypertensive Women.(relationship between hormone therapy and heart attack)
2001 MAR 15 - (NewsRx.com & NewsRx.net) -- With the completion of a study by researchers at the University of Washington, the relationship between hormone replacement therapy and myocardial infarction is a little clearer.
The study, published in the February 21, 2001, edition of the Journal of the American Medical Association, shows a possible link between the presence of a genetic variant associated with blood clotting and the risk of non-fatal myocardial infarction (MI) in hypertensive women taking hormone replacement therapy (HRT).
The lead author of the study is Dr. Bruce M. Psaty, a professor of medicine, epidemiology and health services and co-director of the UW's Cardiovascular Health Research Unit. He and his co-authors studied the prothrombin gene in a case-control study conducted at Group Health Cooperative, a health system based in Seattle, Washington. Prothrombin (factor II) is a protein essential for the clotting of blood. The prothrombin gene variant (G20210A) occurs in 2% to 4% of the population and increases the risk of blood clots in the legs.
The investigators studied 232 post-menopausal women who suffered a first non-fatal MI between 1995 and 1998. The control group included 723 postmenopausal women matched to the cases by age, calendar year of the cardiac event, and hypertension status. In women with hypertension, the effects of HRT on MI risk depended on the prothrombin gene. Among women who did not have the genetic variant, HRT users had a slightly lower risk of MI than women who did not use HRT. Among women with the prothrombin gene variant, however, HRT users had an eight-fold higher risk of MI than women who did not use HRT. Although the number of women with the prothrombin variant was small, the MI risk associated with HRT use differed markedly between those with and ...
- HRT after the menopause.(hormone replacement therapy)(Clinical report)
- Magazine article from: Practice Nurse May 11, 2007 700+ words
...studies, providing important new data about HRT, are set to cause further worry and confusion...think very carefully about whether to take HRT and to weigh up the benefits against the...ovarian and breast cancers associated with HRT, and the third showed that HRT may protect...
- HRT--getting the balance right: what are the risks and what can it promise?...
- Magazine article from: Choice (Chippendale, Australia) January 1, 2003 700+ words
...future over hormone replacement therapy (HRT) and breast cancer. For weeks after the...stopped early because it found the risks of HRT exceeded the benefits, you couldn't avoid...clinical trial to look at the effects of HRT on rates of heart disease, cancer and osteoporosis...
- HRT COMPLIANCE.(hormeone replacement therapy)(Statistical Data Included)
- Magazine article from: Practice Nurse Hirons, Ruth February 9, 2001 700+ words
...replacement and lead to longer-term use. KEY POINTS * HRT is underused * Women need more information on the...that only 17% of women aged 40-65 were taking HRT.[2] Even when women do try HRT, many discontinue it well before they have had a...
- HRT Reduces Left Ventricular Mass In Hypertensives.(hormone replacement therapy)
- Magazine article from: Family Practice News ZOLER, MITCHEL L. May 1, 1999 700+ words
HRT's effect on LDL shown for the first time...of Cardiology Hormone replacement therapy (HRT) reduced left ventricular mass in an 18...almost 50% lower in those who used transdermal HRT than in those using a placebo patch. "Left...
- HRT - the pros and cons of a natural alternative . . .
- News wire article from: Europe Intelligence Wire August 12, 2003 700+ words
...Women are now being told that some kinds of HRT have a much greater effect on a woman...others and that current users of all types of HRT, including oestrogen-only, combined...compared with women who have never used HRT. It's a devastating revelation, but...
- HRT, antioxidants, and atherosclerosis. (Clinical Abstracts).
- Newspaper article from: Alternative Therapies in Women's Health Hardy, Mary February 1, 2003 700+ words
...determine whether hormone replacement therapy (HRT) or antioxidant (AO) vitamin supplements...measured in mean (SD) change, worsened with HRT by 0.047 (0.15) mm/y and by 0.024 (0.15) mm/y with HRT placebo (P = 0.17); and for AO vitamins...
- HRT may reduce risk of type 2 diabetes by 35%. (Negatives may Outweigh...
- Magazine article from: Family Practice News Tucker, Miriam E. February 15, 2003 700+ words
...diabetes was 6.2% among those assigned to HRT, compared with 9.5% among those assigned...placebo, for a 35% reduction in risk in the HRT arm (Ann. Intern. Med. 138[1]:1...HERS data published last summer showed that HRT use did not reduce the risk of cardiovascular...
- HRT Linked to Higher Risk Of Adult-Onset Asthma.
- Magazine article from: Family Practice News BOSCHERT, SHERRY December 15, 2000 700+ words
Factor to discuss when weighing HRT use. SAN FRANCISCO -- Hormone replacement...never been on hormone replacement therapy (HRT). Current use of estrogen plus progestin...compared with those who had never used HRT. All data were adjusted to account for...
- HRT: yes or no? The recent findings on hormone replacement therapy sent women...
- Magazine article from: Good Housekeeping Fox, Cynthia November 1, 2002 700+ words
...to increase until a woman had been using HRT for four years (although the risk for blood...researchers had not challenged the fact that HRT is a strong remedy for hot flashes and vaginal...complaints. The study also showed that HRT reduces a woman's risk for colon cancer...
- HRT: what you need to know: risks of hormone replacement therapy can impact...
- Magazine article from: Review of Optometry Hoscheit, Ann M. August 15, 2003 700+ words
...ll look at the issue of hormone replacement therapy (HRT), including the most recent research and clinical...inform our patients about the risks vs. benefits of HRT. Out With the Old HRT is the use of both estrogen and progesterone, or any...
Source: HighBeam Research, Possible Drug-Gene Interaction Associated With Heart Attacks In...