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Age And Co-Existing Diseases Impact Treatment Options And Risk Of Death.(in postmenopausal women with breast cancer)
2001 MAR 8 - (NewsRx.com) -- Age and the presence of co-existing or additional diseases limit diagnostic tests and examinations, narrow treatment choices, and are associated with risk of early mortality in postmenopausal women with breast cancer, especially those aged 70 years and older, according to an article in the February 21, 2001, issue of The Journal of the American Medical Association.
A collaborative study was conducted by the National Institute on Aging (NIA) and National Cancer Institute (NCI), both of the U.S. National Institutes of Health, to document the co morbidity burden of postmenopausal breast cancer patients and evaluate its relationship with age on disease stage, treatment, and early mortality.
"There is a major gap in information on the pre-existing health conditions that women have in addition to newly diagnosed breast cancer," said lead author Rosemary Yancik, PhD, from the NIA, in an interview. "We need to expand this knowledge base. We want to know what are those other conditions and how they interact with the breast cancer."
The NIA/NCI study included a population-based random sample of 1,800 postmenopausal breast cancer patients diagnosed in 1992. They were divided into three age groups: 55 to 64 years, 65 to 74 years, and 75 years and older. Patients were followed up until death, or for 30 months from breast cancer diagnosis.
According to background information cited in the study, breast cancer ranks second after lung cancer as the leading cause of cancer deaths among women in the United States. A total of 192,200 new cases and 40,200 deaths are estimated for 2001. Sixty-six percent of breast tumors and 77% of breast cancer deaths occur among postmenopausal women aged 55 and older. Postmenopausal breast cancer patients frequently have one or more pre-existing diseases at the time of diagnosis (e.g., heart disease, chronic obstructive pulmonary disease, diabetes, hypertension, and arthritis).
Among the 1,800 women in the study, 1,312 (73%) were diagnosed with stage I and II breast cancer; 188 (10%) with stage III and IV breast cancer, and 300 (17%) did not have a stage assignment.
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