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Outcomes For Pregnant Patients Good With Careful Monitoring.(pregnant autoimmune hepatitis patients have chance for good outcomes)
2001 MAR 8 - (NewsRx.com) -- by Sonia Nichols, staff medical writer -- Scientists report women with autoimmune hepatitis can have good outcomes with pregnancy as long as their hepatitis is controlled and their pregnancies are carefully monitored.
"There is a paucity of data in the literature on the risks associated with, and optimal management of, pregnancy in patients with autoimmune hepatitis (AIH)," said M.A. Heneghan et al. of Duke University's Division of Gastroenterology.
The researchers performed a review of patient records from AIH cases that covered the years from 1983 to 1998. A total of 162 women were identified.
"Thirty-one live births (one twin) resulted from 35 pregnancies in 18 women (even with cirrhosis)," the researchers found.
While many of the women managed to carry their pregnancies to term, there were some early and late fetal losses ("Management and outcome of pregnancy in autoimmune hepatitis," Gut, 2001;48(1):97-102).
"Fetal loss at greater than or equal to 20 weeks' gestation occurred in two instances," Heneghan et al. said. The women had been taking azathioprine alone or with prednisolone, or prednisolone alone.
Birth defects in infants born of mothers with AIH were ...
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