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Glycoprotein 120 Responses Can Determine Infection Or Immunity.(Brief Article)
2001 MAR 21 - (NewsRx.com & NewsRx.net) --
by Michael Greer, staff medical writer -- HIV glycoprotein 120 (gp120) may be able to help identify both infection and incipient immunity.
Florian Hadlik and colleagues evaluated the usefulness of delayed-type hypersensitivity (DTH) reactions for determining HIV specific T-cell activity.
Two days after intradermal injections of recombinant gp120, DTH reactions were common among both infected patients and uninfected vaccinees, they found. However, a substantial proportion of uninfected subjects displayed DTH-like reactions a week or more after exposure, several of whom subsequently showed gp120-specific antibodies.
No uninfected subject displayed a DTH-like reaction within 48 hours of recombinant gp120 exposure ("Recombinant HIV-1 glycoprotein 120 induces distinct types of delayed hypersensitivity in persons with or without pre-existing immunologic memory," Journal of Immunology, March 2001;166:3580-3588).
This DTH-like reaction consisted of a hardening of the skin similar to that observed in true DTH responses. However, the marked delay in onset and lack of previous viral exposure differentiated this reaction from true DTH, Hadlik et ...
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Source: HighBeam Research, Glycoprotein 120 Responses Can Determine Infection Or Immunity.(Brief...