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Understanding Genetic Predisposition May Lead To Vaccine.(Brief Article)
2001 MAR 21 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer -- Better understanding of a genetic tendency for contracting malaria may lead to vaccine development.
Families appear to inherit the tendency to contract or resist Plasmodium faciparum, the pathogen responsible for malaria, noted researchers studying family groups in Burkina Faso.
"Host genes are thought to determine the immune response to malaria infection and the outcome," explained C. Aucan and colleagues at the Universite Mediterranee in France. "Cytophilic antibodies have been associated with protection, whereas noncytophilic antibodies against the same epitopes may block the protective activity of the protective ones."
The researchers analyzed the immunoglobulin G (IgG) responses of 366 people living in two areas of Burkina Faso with different exposures to P. falciparum.
The researchers calculated sibling-sibling and parent-child correlations in disease response ("Familial correlation of immunoglobulin g subclass responses to Plasmodium falciparum antigens in Burkina Faso," Infection and Immunity, 2001;69(2):996-1001).
They found both sibling-sibling and parent-child correlations for IgG, IgG1, IgG2, IgG3, and IgG4 responses. Resistance patterns appeared to ...
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