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Protective Immunity Against HAV Eventually Declines In Graft Recipients.(Brief Article)
2001 MAR 21 - (NewsRx.com & NewsRx.net) --
by Sonia Nichols, staff medical writer -- Protective immunity developed after immunization with the hepatitis A vaccine gradually weakens in liver and kidney transplant recipients.
Within a few years of hepatitis A virus (HAV) vaccination, liver and kidney transplant patients will lose protective antibodies against the virus. Organ transplant recipients must often take immunosuppressive therapies after transplantation. Authors of a new study report these patients remain highly susceptible to new HAV infections as their protective antibody levels fall.
Researchers in Germany at the Humboldt University of Berlin compared post-vaccination antibodies against HAV in liver and kidney transplant patients, and in healthy controls. Each group was given two doses of vaccine ("Rapid decline of antibodies after hepatitis A immunization in liver and renal transplant recipients," Transplantation, 2001;71(3):455).
When vaccine schedules were completed, new organ recipients had developed sufficient protection against HAV. "However, two years later they had experienced a much more rapid antibody decline than ...
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