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DNA Vaccines Offer Protection From Strain B In Mouse Study.(Brief Article)
2001 MAR 21 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer -- Two plasmid DNA vaccines appear to confer protection from influenza B virus in mice.
"Protection against a lethal influenza B virus infection was examined in BALB/c mice immunized with plasmid DNAs encoding hemagglutinin (HA), neuraminidase (NA and NE), and nucleoprotein (NP) from the B/Ibaraki/2/85 virus," said Z. Chen and colleagues working in Japan.
Mice were inoculated twice, three weeks apart, then challenged with a lethal dose of homologous influenza B three weeks later.
Chen and team found that two of the DNA vaccines, HA and NA, conferred complete protection, while the other two, NE and NP, offered no protection ("Protection against influenza B virus infection by immunization with DNA vaccines," Vaccine, 2001;19(11-12):1446-1455).
The successful vaccines, HA and NA, were then tested on additional strains of mice, with identical success.
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