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Sequential Use Of Different Vaccines Can Improve Effectiveness.(Brief Article)
2001 MAR 21 - (NewsRx.com & NewsRx.net) --
by Michael Greer, staff medical writer -- A series of vaccinations using formulations with different attenuations may improve the chances of HIV prevention.
A. Kumar and colleagues at the University of Kansas used four rhesus macaques to study the effectiveness of sequential immunization with vaccines for two different strains of simian HIV (SHIV).
Subsequent challenge with a potent form of SHIV showed that viral replication in vaccinated animals was up to 60,000 times less efficient than in control animals, the research team found.
Although levels of CD4(+) cells dropped briefly after three weeks, T-cell levels remained constant for the most part throughout the 85-week observation period, study data showed. By contrast, all control animals died within 81 weeks of SHIV exposure ("Sequential immunization of macaques with two differentially attenuated vaccines induced long-term virus-specific immune responses and conferred protection against AIDS caused by heterologous simian human immunodeficiency virus (SHIV89.6P)," Virology, 2001;279(1):241-256).
Vaccinated animals developed binding antibodies against glycoproteins from both vaccine SHIV strains ...
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Source: HighBeam Research, Sequential Use Of Different Vaccines Can Improve Effectiveness.(Brief...