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Nasal Vaccine Against Human Papillomavirus May Prevent Transmission.(Brief Article)
2001 MAR 21 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer -- A vaccine that inhibits the growth of human papillomavirus 16 (HPV16) in mice may ultimately be used to help women stimulate their own immune systems to fight off the infection that causes cervical cancer.
Researchers have theorized that some women are naturally able to resist infection with HPV16 with the help of anti-HPV16-specific antibodies, though no adequate experimental model exists to test the theory.
"Induction of HPV16-specific cell-mediated immunity in the genital mucosa could improve the efficacy of a vaccine and a mucosal route of immunization might be necessary to do so," suggested V. Revaz and colleagues.
Previous studies have shown that systemic immunization of mice with HPV16 virus-like particles (VLPs) protects them from subsequent challenge with the virus. In this experiment, researchers used an intranasal vaccine ("Mucosal vaccination with a recombinant Salmonella typhimurium expressing human papillomavirus type 16 (HPV16) L1 virus-like particles (VLPs) or HPV16VLPs purified from insect cells inhibits the growth of HPV16-expressing tumor cells in mice," ...
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- Magazine article from: British Medical Journal Strickler, Howard D. Schiffman, Mark H. September 13, 1997 700+ words
...demonstrate in the study of human papillomavirus infection as a cause of...In cervical cancers human papillomavirus DNA can be detected in...Moreover, cervical human papillomavirus has been detected before...
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...smoking and infection with oncogenic human papillomavirus. It has been suggested that smoking...the infection and persistence of human papillomavirus. Design--Cross sectional epidemiological...analysis of cervical scrapes for human papillomavirus, and morphological examination...
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- Magazine article from: British Medical Journal Burger, M.P.M. Hollema, H. Pieters, W.J.L.M. Quint, W.G.V. January 14, 1995 700+ words
...The broad spectrum of different human papillomavirus types has recently been grouped...tree lead to specific groups of human papillomavirus types with similar tissue tropism...viruses such as types 31 and 33. Human papillomavirus type 18 belongs to a separate main...
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- Magazine article from: British Medical Journal Hines, Jeffrey F. Ghim, Shin-Je Jenson, A. Bennett March 2, 1996 700+ words
...existing scientific evidence of human papillomavirus and its association with invasive...To date, more than 70 types of human papillomavirus have been described. Each type...between anogenital infection with human papillomavirus and the development of cervical...
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- Magazine article from: British Medical Journal Sonnex, C. Scholefield, J.H. Kocjan, G. Kelly, G. Whatrup, C. Mindel, A. Northover, J.M.A. November 16, 1991 700+ words
...subclinical manifestations of anal human papillomavirus infection have been well reported...the prevalence of subclinical anal human papillomavirus infection in heterosexual people...previously. The mode of transmission of human papillomavirus to the anus is poorly understood...
Source: HighBeam Research, Nasal Vaccine Against Human Papillomavirus May Prevent...