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Vaccine Prevents Hyper-Responsiveness In Mice.(Brief Article)
2001 MAR 21 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer -- Mice inoculated with bacillus Calmette-Guerin (BCG) vaccine 10 days after birth appear able to block an immune hyper-responsiveness characteristic of asthma by 16 weeks of age.
Researchers working in France explored the idea that asthma is an over-response of T-helper lymphocyte phenotype 2 (Th-2) in children who have not been previously exposed to Th-l-inducing infections.
"We tested the hypothesis that BCG vaccination in Th-2-susceptible newborn BP2 mice blocks allergic inflammation and bronchial hyper-reactivity (BHR)," explained M.A. Nahori and colleagues.
The researchers inoculated 10-day-old mice intranasally with BCG 1173P2 (10(5) CFU), and then challenged them with two 100 (micro)g doses of ovalbumin in aluminum hydroxide at one week intervals at six, 10, or 14 weeks thereafter. After the second inoculation, the mice were challenged with 10 (micro)g ovalbumin intranasally ("Effects of Mycobacterium bovis BCG on the development of allergic inflammation and bronchial hyper-responsiveness in hyper-IgE BP2 mice vaccinated as newborns," Vaccine, 2001;19(11-12):1484-1495).
Mice that were vaccinated with BCG eight weeks before challenge experienced severe bronchial inflammation and hyper-reactivity, and high levels of immunoglobulin (IgE).
"Inflammation involved T cells, macrophages, dendritic cells, and was accompanied by increased levels of interleukine 5 (IL-5) in the bronchoalveolar ...
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Source: HighBeam Research, Vaccine Prevents Hyper-Responsiveness In Mice.(Brief Article)