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StaphVAX Elicits Antibodies With In Vitro Activity Against Antibiotic-Resistance.
2001 MAR 14 - (NewsRx.com & NewsRx.net) --
New in vitro data confirm that human antibodies elicited by Nabi(R) StaphVAX(R) (Staphylococcus aureus Polysaccharide Conjugate Vaccine), an investigational vaccine under development to protect at-risk patients from S. aureus blood infections, might be able to combat both antibiotic-resistant as well as antibiotic-sensitive strains of the bacteria.
The new laboratory findings were presented February 22, 2001, at the U.S. Centers for Disease Control and Prevention Advisory Committee on Immunization Practices meeting in Atlanta, Georgia. Gary Horwith, MD, Nabi, discussed the research.
Antibiotic resistance in S. aureus is a serious and growing problem for community-acquired infections as well as infections acquired in the hospital. Almost all S. aureus isolates are resistant to penicillin, and over 55% are now resistant to methicillin (MRSA strains). Moreover, S. aureus strains with notably reduced sensitivity to vancomycin (VISA strains) have been isolated in 23 states within the United States, as well as in Europe and Japan.
"The National Institutes of Health Network on Antimicrobial Resistance in Staphylococcus aureus (NARSA) maintains a repository of VISA strains. Of the 15 strains received and tested by Nabi, 14 were type 5 and one was type 8. These results suggest that most VISA strains of S. aureus contain either type 5 or type 8 capsular polysaccharides. Further, in a S. aureus infection model, animals immunized with StaphVAX and challenged with representative VISA strains were protected against infection," said Horwith.
S. aureus type 5 and type 8 account for 85%-90% of all clinically significant S. aureus infections. ...
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Source: HighBeam Research, StaphVAX Elicits Antibodies With In Vitro Activity Against...