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New Animal Model Will Facilitate Vaccine Development.(golden hamster to serve as a model for a vaccine against leishmaniasis)
2001 MAR 7 - (NewsRx.com & NewsRx.net) --
by Michelle Marble, staff medical writer -- The golden hamster will help researchers develop a vaccine against leishmaniasis, say scientists in Spain.
"For experimental infections with viscerotrophic strains of Leishmania, a suitable animal model is not yet defined," said J.M. Requena and colleagues, University Autonoma Madrid. "In the present work, we have reappraised the use of golden hamster (Mesocricetus auratus) as an experimental model for infection with Leishmania infantum."
Requena et al. published the results of their study in the journal Veterinary Immunology and Immunopathology.
The researchers challenged several groups of hamsters by the intracardial route with doses of L. infantum. The doses ranged from 10(3) to 10(5) infectious promastigotes. After being infected, the animals were monitored for a one-year follow-up period.
The authors assessed clinical symptoms, measuring parasite loads in both liver and spleen, and noting humoral response to Leishmania antigens and antibody levels in the kidneys of the infected animals. They analyzed humoral responses using either crude antigens (by enzyme-linked immunosorbent assay [ELISA] and Western blotting) or several recombinant Leishmania antigens (Hsp70, Hsp83, LiP2a, LiP2b, H2A, H3, and KMP-11).
...- First golden hamster offspring produced by round spermatid oocyte injection.
- Newspaper article from: Medical Devices & Surgical Technology Week August 29, 2004 700+ words
2004 AUG 29 - (NewsRx.com & NewsRx.net) -- Golden hamster offspring have been produced through ROSI for the first time. "The golden hamster is a mammal in which microinjection of round spermatids into oocytes (ROSI) was first attempted...
- West Nile Virus Infection in the Golden Hamster (Mesocricetus auratus): A Model...
- Magazine article from: Emerging Infectious Diseases Xiao, Shu-Yuan Guzman, Hilda Zhang, Hui da Rosa, Amelia P.A. Travassos Tesh, Robert B. July 1, 2001 700+ words
This report describes a new hamster model for West Nile (WN) virus encephalitis. Following intraperitoneal inoculation of a New York isolate of WN virus, hamsters had moderate viremia of 5 to 6 days in duration, followed by the development of humoral antibodies. Encephalitic symptoms began 6 days
- Oligomerization of proteolytic products in prions shown.
- Newspaper article from: Vaccine Weekly December 15, 2004 700+ words
...of recombinant human (rhPrP), golden hamster (rmaPrP) prion proteins as well...This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx...
- WNV vaccine shows 100% protection in animal study, company reports.
- Newspaper article from: Vaccine Weekly August 4, 2004 700+ words
...of human West Nile disease, the golden hamster, developed at the University of...This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx...
- Hawaii Biotech says its West Nile vaccine shows 100% protection.
- Newspaper article from: Vaccine Weekly August 20, 2003 700+ words
...well-validated model of human West Nile disease, the golden hamster, developed at the University of Texas Medical Branch...time during the study. This article was prepared by Vaccine Weekly editors from staff and other reports.
- Human hookworm maintained through 100 generations in golden hamsters.
- Newspaper article from: Vaccine Weekly October 29, 2003 700+ words
...was maintained through one hundred generations in the golden hamster (Mesocricetus auratus)," researchers in China and...and Infectious Disease. This article was prepared by Vaccine Weekly editors from staff and other reports.
- Hamsters
- Encyclopedia entry from: The Gale Encyclopedia of Science Freedman, Bill January 1, 2008 700+ words
...their burrows, or using dogs. The golden hamster (Mesocricetus auratus) is a very...Middle East. For about a century, the golden hamster was only known from a single specimen...group. The head and body length of the golden hamster is about 6 in (17 – 18 cm...
- New Animal Model Will Facilitate Vaccine Development.
- Newspaper article from: TB & Outbreaks Week March 6, 2001 700+ words
...Marble, staff medical writer -- The golden hamster will help researchers develop a vaccine...work, we have reappraised the use of golden hamster (Mesocricetus auratus) as an experimental...Leishmania infantum infection in the golden hamster model," Vet Immunol Immunopathol...
