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CpG Motifs Have Therapeutic Potential.(for vaccines, immunotherapies, and gene therapy)
2001 MAR 7 - (NewsRx.com & NewsRx.net) --
by Michelle Marble, staff medical writer -- CpG motifs may influence the success of vaccines, immunotherapies, and gene therapies, Genzyme Corp. researchers suggest.
"The mammalian immune system has evolved mechanisms to recognize and respond to 'danger' signals arising from pathogens," said R.K. Scheule and colleagues at Genzyme. "Among those danger signals are the unmethylated CpG dinucleotide motifs found in bacteria."
According to the researchers, cytokines released by macrophages and related cells in response to CpG motifs are then responsible for activating other immune cells. These other immune cells, such as natural killer (NK) cells and T cells, help mediate the development of adaptive immune responses, Scheule et al. wrote in the journal Advanced Drug Delivery Reviews.
Small oligodeoxynucleotides containing stimulatory CpG motifs may also have the ability to induce these pro-inflammatory Th1 responses. As such, when generated intentionally, they may have potential use as vaccine adjuvants and for cancer immunotherapy ("The role of CpG motifs in immunostimulation and gene therapy," ...
- Direct evidence of TLR9 interaction with CpG motifs reported.
- Newspaper article from: Drug Week May 28, 2004 700+ words
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BERKELEY, Calif., Sept. 2 /PRNewswire/ -- Dynavax Technologies today announced the development and characterization of a novel series of CpG-containing molecules with potent immune regulation activities in human cells. These molecules, termed Chimeric Immunomodulatory Compounds (CICs), consist of
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- Gene therapy industry should see brighter days.(Bruce A. Hironaka of Cell...
- Magazine article from: San Diego Business Journal Webb, Marion November 16, 1998 700+ words
Today's gene therapy business looks "bleak," admits...opportunities at last week's third annual Gene Therapy and Genomics meeting at the Westin...There will be a significant demand for gene therapy," Hironaka said in a cheery introductory...
- Gene therapy benefit said to outweigh risk.
- News wire article from: United Press International October 10, 2002 700+ words
...International via COMTEX) The benefits of gene therapy far outweigh its risks and such procedures...emergency meeting Thursday to examine gene therapy safety issues following the report last...In addition, a clinical trial of gene therapy in France being conducted at the Hopital...
