AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Protein Up-Regulated By VEGF Is Suitable Target.(for immunotherapy)
2001 MAR 7 - (NewsRx.com & NewsRx.net) --
by Sonia Nichols, staff medical writer -- The properties of CD55, a cell membrane protein that neutralizes complement activation, make it a good candidate for immunotherapy targeting.
Laboratory analysis has recently shown that an antigen called 791Tgp72 is actually CD55, according to scientists at the University of Nottingham, U.K. This antigen has been used for imaging studies and therapies directed towards cancer cells. L. Li and colleagues propose that cells expressing this protein could be used for targeted drug therapies.
Li et al. compared the expression of CD55 in normal cells with expression in tumor cells ("CD55 is over-expressed in the tumor environment," British Journal of Cancer, 2001;84(1):80-86).
"Tumor cells showed a four- to 100-fold increase in CD55 cell surface expression when compared to normal cells," Li's group said.
When colorectal tumors were examined, CD55 was highly expressed in the stromal areas of those tumors, the researchers said. Further analysis of tumor cells grown in culture led investigators to observe deposition of CD55 into adjacent extracellular matrices, where they found that the quantity of extracellular deposition was directly proportional to ...
- Bacteroides fragilis DNA inversions regulate cell surface adaptation.
- Newspaper article from: Vaccine Weekly December 29, 2004 700+ words
...inversions regulating cell surface adaptation. According...inversions regulating cell surface adaptation. Proc...article was prepared by Vaccine Weekly editors from staff...Copyright 2004, Vaccine Weekly via NewsRx.com...
- Hopkins Scientists Uncover 'Tags' That Force Proteins to Cell Surface;...
- News wire article from: AScribe Medicine News Service September 22, 2005 700+ words
...discovered. Because proteins on the cell surface are "lock-on" sites for drugs and...if you can't get the protein to the cell surface, you can't use this screening technique. If we can force proteins to the cell surface, we can overcome obstacles that have...
- Sweet Success in Targeting Cell Surface.
- News wire article from: Ascribe Higher Education News Service August 18, 2004 700+ words
...researchers said the new approach to marking cell-surface sugars could lead to improved understanding...development. But studying the role of cell surface sugar chains, called polysaccharides...sugars and are incorporated into the cell-surface polysaccharides. The researchers can...
- Cell surface targets identified for HIV-1 therapeutics using genetic screens.
- Newspaper article from: Gene Therapy Weekly June 24, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Cell surface targets are identified for HIV-1 therapeutics...from a diverse set of genes including cell surface receptors, cytokines, signaling proteins...GSEs were derived from the following 12 cell surface proteins: CXCR4, CCR4, CCR7, CD11C...
- Cell surface heparan sulfate participates in chemokine-induced signaling.
- Newspaper article from: Angiogenesis Weekly March 28, 2003 700+ words
...NewsRx.com & NewsRx.net) -- Cell surface heparan sulfate participates in chemokine...CHO-K1 cells is dependent on the presence of cell surface HSPGs. The cell surface HSPGs on cells are required for CXCL I induced...
- Tetraspanins form functional cell surface microdomains in leukocytes.
- Newspaper article from: Blood Weekly January 22, 2004 700+ words
...NewsRx.net) -- Tetraspanins are cell surface proteins that form functional microdomains...tetraspanins are a large superfamily of cell surface membrane proteins characterized by their...thought to organize a novel type of cell surface membrane microdomain, which in leukocytes...
- Kringle 1-5 requires cell surface ATP synthase to stop angiogenesis.
- Newspaper article from: Cancer Weekly July 20, 2004 700+ words
...NewsRx.net) -- Kringle 1-5 requires cell surface ATP synthase to stop angiogenesis...show that K1-5 bound to endothelial cell surface ATP synthase and triggered caspase...its interaction with the endothelial cell surface ATP synthase and that the caspase...
- Significance of nano- and microtopography for cell-surface interactions in...
- Magazine article from: Journal of Biomedicine and Biotechnology Jager, M. Zilkens, C. Zanger, K. Krauspe, R. January 1, 2007 700+ words
Cell-surface interactions play a crucial role for...Therefore, the understanding of cell-surface interactions is of major interest...mechanisms of nano- and microscale cell-surface interactions in vitro for different...
Source: HighBeam Research, Protein Up-Regulated By VEGF Is Suitable Target.(for immunotherapy)