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Second-Generation Vaccine Has Blocking Action Against Cocaine.(second-generation immunoconjugate GND-keyhole limpet hemocyanin vaccine)
2001 MAR 7 - (NewsRx.com & NewsRx.net) --
by Michelle Marble, staff medical writer -- The psychoactive effects of cocaine can be blocked with a vaccine, say researchers.
Rats immunized with a second-generation immunoconjugate vaccine, GND-keyhole limpet hemocyanin, showed dramatic decreases in responses to cocaine that lasted through numerous challenges, said researchers at The Scripps Research Institute, La Jolla, California.
M. Rocco and colleagues tested the "effects of immunization with the second-generation cocaine immunoconjugate GND-keyhole limpet hemocyanin (KLH) or with the anti-cocaine mAb GNC92H2." They published their report in the Early Edition of the Proceedings of the National Academy of Sciences.
Rocco et al. administered 15 mg/kg of cocaine HCL to rats intraperitoneally (i.p.). After being given the cocaine, the rats were tested in photocell cages. The researchers measured stereotypical reactions to determine pre-immunization drug response (baseline).
Next, the rats were immunized with GND-KLH or treated with the monoclonal antibody (MAb) GNC92H2. After immunization, the rats were challenged with systemic administration of cocaine and their motor responses were again measured in the same test as before.
"Active immunization with GND-KLH produced a 76% decrease in the ambulatory measure (crossovers) in the experimental group and a 12% increase in the control group compared with baseline values," said Rocco et al. "Also, stereotypic behavior was significantly suppressed in the vaccinated animals."
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