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Connective Tissue Growth Factor Found in Human Uterine Tissue.
2001 FEB 22 - (NewsRx.com) -- by Sonia Nichols, staff medical writer -- The mitogenic connective tissue growth factor (CTGF) has now been observed in tissues of the human uterus, and is believed to play a part in regulatory mechanisms important to female reproduction.
"This study is the first to demonstrate CTGF gene expression and localization of its encoded protein in human uterine tissues," said lead investigator M. Uzumcu and colleagues from Washington State University in Molecular Human Reproduction.
CTGF was significantly expressed in several types of cells during the different stages of menarche, and again during pregnancy. Fixed human samples of uterine tissue were tested for CTGF during the proliferative stage and the several secretory stages. Cells representing uterine tissue expression during pregnancy were also evaluated. In addition, investigators tested human myometrium and leiomyomas.
During the proliferative stage, CTGF expression was strongest in endothelial and vascular cells, and weakest in stromal cells.
Uzumcu et al. said, "Throughout the entire secretory stage, CTGF was detected in epithelial and endothelial cells of endometrium."
Stromal cells produced the most CTGF in areas of ...
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Source: HighBeam Research, Connective Tissue Growth Factor Found in Human Uterine Tissue.