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Vascular Endothelial Growth Factor Marks Survival.(for patients with endometrial cancer)
2001 FEB 22 - (NewsRx.com) -- by Sonia Nichols, staff medical writer -- New research indicates vascular endothelial growth factor (VEGF) is an important marker for survival in patients with endometrial carcinoma.
The growth factor, which plays a key role in tumor-related angiogenesis, is a significant marker for different types of cancer, according to a report published in the February 2001 edition of Gynecologic Oncology. Researchers at National Taiwan University College of Medicine have established its relation to endometrial cancer progression and survival in females.
The research team, headed by Chi-An Chen, studied tumor samples acquired during surgery from 53 patients with endometrial cancers. These samples were assessed for cytosol VEGF, microvessel density, and other pathological features. VEGF often joins microvessel density (MVD) as an indicator of neovascularization within cancer tumors.
Patients with more advanced stages of endometrial cancer exhibited higher levels of VEGF and demonstrated greater MVD values also, according to Chen et al. These higher levels also correlated with findings of lymphovascular emboli and lymph node metastasis.
As values for VEGF increased, so did values for MVD. "Grade 3 tumor and overexpressed cytosol VEGF ([less than] 800 ...
- Gene transfection downregulates VEGF expression in endometrial cancer cells.
- Newspaper article from: Cancer Gene Therapy Week August 4, 2003 700+ words
...transfection downregulates VEGF expression in endometrial cancer cells. "It has been...endothelial growth factor (VEGF) expression, but...gene transfection. VEGF expression was downregulated...factor expression in endometrial cancer cells. Exp Mol Pathol...
- VEGF Growth Factors Are Markers For Metastasis And Survival.(vascular...
- Magazine article from: Women's Health Weekly Henderson, CW March 15, 2001 700+ words
...VEGF), VEGF-A/VEGF-1 and VEGF-C/VEGF-2, are differentially expressed by endometrial cancer cells, according to researchers...and metastasis in postmenopausal endometrial cancer * VEGF-C/VEGF-2 expression, uterine...
- ARIAD Initiates Phase 2 Clinical Trial of AP23573 in Patients with Recurrent or...
- Press release article from: Business Wire June 30, 2005 700+ words
...of ARIAD. About Endometrial Cancer It is expected that...000 new cases of endometrial cancer will be diagnosed...deaths will occur. Endometrial cancer, which develops...Endothelial Growth Factor (VEGF) in tumor and endothelial...
- New endometrial cancer research reported from K. Takahashi and...
- Newspaper article from: Cancer Weekly November 10, 2009 700+ words
...mutations in the human endometrial cancer cell line HEC1A...report (see also Endometrial Cancer). "EGFR expression...and invasion and VEGF-A production in...using cetuximab for endometrial cancer." Takahashi and...
- Endometrial Cancer
- Encyclopedia entry from: Gale Encyclopedia of Medicine, 3rd ed. Cherath, Lata; Rowland, Belinda January 1, 2006 700+ words
Endometrial Cancer Definition Endometrial cancer develops when the cells that make up the inner lining...become abnormal and grow uncontrollably. Description Endometrial cancer (also called uterine cancer) is the fourth most common...
- Uterine Cancer (Endometrial Cancer).(Brief Article)
- Clinical Reference Systems November 1, 1999 700+ words
What is endometrial cancer? Endometrial cancer is a condition in which cancer cells grow in the lining...is also called uterine cancer. How does it occur? Endometrial cancer is seen most often in older women between the ages of...
- Uterine Cancer (Endometrial Cancer).
- Clinical Reference Systems July 1, 1999 700+ words
What is endometrial cancer? Endometrial cancer is a condition in which cancer cells grow in the lining...is also called uterine cancer. How does it occur? Endometrial cancer is seen most often in older women between the ages of...
- Endometrial Cancer.(Cancers Common to Women)
- The Columbia Univ. Coll. of Physicians & Surgeons Complete Home Medical Guide Antman, Karen H. January 1, 1995 700+ words
Endometrial Cancer Definition The endometrium lines the inner surface of the uterus. Endometrial cancer develops mostly in women between...estimated 31,000 new cases of invasive endometrial cancer occur each year in the United States...