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Ovarian Stimulation in Mice Adversely Affects Embryo Development and Implantation.
2001 FEB 15 - (NewsRx.com) -- Research has shown that, in mice, stimulating the ovaries by hormone drugs to produce more eggs appears to impair both the development of the embryo and its likelihood of implanting in the uterus.
Dr. Gudvor Ertzeid and Dr. Ritsa Storeng from The National Hospital, University of Oslo, Norway, undertook the study to establish whether impaired embryo quality or changes in the environment in the uterus could be responsible for the observed adverse effects of superovulation on implantation and fetal development in mice ("The impact of ovarian stimulation on implantation and fetal development in mice," Human Reproduction, February 2001;16(2):221-225).
They used four groups to evaluate the impact of ovarian stimulation on embryo quality and uterine receptivity:
* embryos from control donors to control foster mothers
* embryos from superovulated donors to control foster mothers
* embryos from control donors to superovulated foster mothers
* embryos from superovulated donors to superovulated foster mothers
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Source: HighBeam Research, Ovarian Stimulation in Mice Adversely Affects Embryo Development and...