AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
HLA Class I Polymorphism and Population Genetics Influence Response.(Brief Article)
2001 FEB 21 - (NewsRx.com & NewsRx.net) --
by Michelle Marble, staff medical writer -- According to a study from the United States, genetic differences in populations influence vaccine efficacy.
"Human leukocyte antigen (HLA) polymorphism can complicate the design and development of vaccines, especially those that contain a selected number of epitopes and are directed at pathogens prevalent worldwide," wrotes D.V. Dawson and colleagues, Case Western Reserve University, Cleveland, Ohio. "Because of HLA class I restricted antigen recognition and ethnic variation in HLA distribution, such vaccines may not be uniformly effective across populations." Dawson et al. published the results of their study in the journal Genetic Epidemiology.
"We, therefore, considered whether it is possible to assemble a panel of HLA-A and/or HLA-B alleles that would allow the formulation of a single vaccine for a set of Caucasian, Black, or Asian populations," continued the authors. "In applying an algorithm to predict levels of favorable response, we identified predominant alleles in 15 representative populations."
The researchers found that roughly 80% of the individuals in one Black-African population and five Asian populations were positive for at least one of three HLA-A alleles. They also determined that 80% coverage was theoretically possible in five Caucasian populations with only five HLA-A alleles. Four of the five Black populations analyzed also required five alleles, but the allelic combinations differed from those in the Caucasian populations.
"Our findings suggest that ...
- HLA class II alleles linked to increased vitiligo risk identified.
- Newspaper article from: Health & Medicine Week May 3, 2004 700+ words
...MAY 3 - (NewsRx.com & NewsRx.net) -- HLA class II alleles associated with an increased risk of...Medical Academy conducted a study "to determine which HLA class I antigens and HLA class II alleles are associated with Turkish vitiligo...
- HLA Class I Allele Loss in Melanoma Cells Is Detrimental.
- Newspaper article from: Immunotherapy Weekly September 20, 1999 700+ words
...com) -- Human leukocyte antigen (HLA) class I allele loss allows melanoma cells...that a single mutational event in an HLA class I gene was sufficient for loss of...for the high frequency of selective HLA class I allele loss in melanoma cells...
- HLA class II alleles not associated with HIV resistance/susceptibility.
- Newspaper article from: World Disease Weekly December 28, 2004 700+ words
...com & NewsRx.net) -- HLA class II alleles are not significantly...HIV resistance/susceptibility. "HLA class II alleles were molecularly typed...Univariate analysis, no significant HLA class II associations with resistance...
- HLA Class II Alleles Mark Therapeutic Response To Sudden Hearing Loss.
- Newspaper article from: Gene Therapy Weekly October 4, 2001 700+ words
...Catholic University of Korea say HLA class II alleles are useful for predicting...Furthermore, patients with two of the HLA class II allele frequencies, DQA1*03...team ("Different distribution of HLA class II alleles according to response...
- HLA class I and II typing may improve SCT outcome.
- Newspaper article from: Biotech Week October 29, 2003 700+ words
...net) -- Human leukocyte antigen (HLA) class I and II typing may improve the outcome...1988 and 1999, were retrospectively HLA class I- and class II-typed by PCR...These results suggest that "genomic HLA class I- and class II-typing may improve...
- Rare HLA class I types correlate with low viral load.
- Newspaper article from: AIDS Weekly July 21, 2003 700+ words
...amounts of virus in their blood. HLA class I molecules bind to peptides from...susceptibility to certain types of HLA class I molecules. Now Steven Wolinksy...Medicine that the presence of rare HLA class I types correlates with low viral...
- HLA class I serotypes important in vaccine efficacy assessments.
- Newspaper article from: Life Science Weekly October 19, 2004 700+ words
...Researchers emphasize the need to assess HLA class I serotypes when determining the...specific human leukocyte antigen (HLA) class I serotypes and the presence of cytotoxic...and the United States report. "HLA class I serotypes A11, A24, A33, B46...
- HLA class I serotypes important in vaccine efficacy assessments.(human...
- Newspaper article from: World Disease Weekly October 19, 2004 700+ words
...Researchers emphasize the need to assess HLA class I serotypes when determining the...specific human leukocyte antigen (HLA) class I serotypes and the presence of cytotoxic...and the United States report. "HLA class I serotypes A11, A24, A33, B46...