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Antigenic Specificity of Infected Cells Defined.(Brief Article)
2001 FEB 21 - (NewsRx.com & NewsRx.net) --
by Michelle Marble, staff medical writer -- What makes an effective vaccine against Mycobacterium tuberculosis? Researchers in the United States want to know.
"Previous studies in murine and human models have suggested an important role for human leukocyte antigen (HLA) Ia-restricted CD8(+) T cells in host defense to Mycobacterium tuberculosis (Mtb)," wrote D.M. Lewinsohn and colleagues, Oregon Health Sciences University. "Therefore, understanding the antigens (Ags) presented via HLA-Ia will be important in understanding the host response to Mtb and in rational vaccine design." Lewinsohn et al. published their study in the Journal of Immunology.
"We have used monocyte-derived dendritic cells in a limiting dilution analysis to generate Mtb-specific CD8(+) T cells," explained the authors. "Two HLA-Ia-restricted CD8(+) T-cell clones derived by this method were selected for detailed analysis."
One of the clones was HLA-B44 restricted, and the other was HLA-B14 restricted. Lewinsohn et al. observed that both reacted with Mtb-infected targets, but neither reacted with bacillus Calmette-Guerin (BCG)-infected targets.
The Ag identified for both clones was culture filtrate protein 10 (CFP10)/Mtb11. This is a 10.8-kDa protein that is not expressed by bacillus Calmette-Guerin. The researchers observed that anti-class I antibody (Ab) and anti-HLA-B,C Abs inhibited both clones ("Classically restricted human CD8(+) T lymphocytes derived from Mycobacterium ...
- HLA-DRB alleles and systemic lupus erythematosus in Jamaicans.
- Magazine article from: Southern Medical Journal Smikle, Monica Christian, Nicole DeCeulaer, Karel Barton, Everard Roye-Green, Karen Dowe, Gwendolyn Anderson, Norma Nicholson, George July 1, 2002 700+ words
...Background. The human leukocyte antigens (HLA) are associated with susceptibility to systemic...different ethnic groups. Methods. A DNA-based HLA-typing method was used to determine alleles of HLA-DRB1, DRB3, DRB4 and DRB5 in Jamaican patients...
- HLA-B27 and Salmonella Infection: The Other Side of the Coin.
- Magazine article from: Infectious Disease Alert August 15, 2000 700+ words
HLA-B27 and Salmonella Infection: The Other...Coin abstract & commentary Synopsis: HLA-B27 positivity, which predisposes to the...outcome in Salmonella-infected patients by HLA-B27. Arthritis Rheum 2000;43:1527...
- Analysis of HLA antigens in Turkish sarcoidosis patients.(human leukocyte...
- Magazine article from: Southern Medical Journal Bilir, Muammer Sipahi, Sevtap Yilmaz, Erkan Midilli, Kenan Yanardag, Halil Cagatay, Tulin Demirci, Sabriye Karayel, Tuncer Erdogan, Ergun April 1, 2007 700+ words
...different ethnic groups. Methods: We studied HLA polymorphisms in 64 Turkish patients with...39 [+ or -] 6.1 years. Frequency of HLA A2, A9, A24 (9), A25, A69 (28...significantly higher, and frequencies of HLA B7 and DR7 were significantly less in sarcoidosis...
- HLA class II alleles linked to increased vitiligo risk identified.
- Newspaper article from: Biotech Week May 5, 2004 700+ words
...5 - (NewsRx.com & NewsRx.net) -- HLA class II alleles associated with an increased...there is an association between vitiligo and HLA complex," scientists in Turkey explained. "HLA subtypes vary with racial/ethnic background...
- Increased graft survival of HLA-matched kidney transplants supports national...
- Newspaper article from: Transplant News Grygotis, Michele October 24, 2000 700+ words
...duration of cold ischemia justifies national sharing of HLA-matched kidney transplants, according to the results...rejection and actuarial graft survival for 7,614 HLA-matched and 81,364 HLA-mismatched cadaveric kidney transplants reported...
- Restriction fragment length polymorphism of HLA-DR and HLA-DG allotypes in four...
- Magazine article from: Human Biology Hawi, Z H; Mastana, S S; Papiha, S S October 1, 1996 700+ words
Abstract HLA-DR and HLA-DQ allele frequencies in four populations (Brahmin, Maratha, Gujarati...probes DRB, DQB, and DQA. Although the overall differences in the HLA-DR and HLA-DQ genotype frequencies among the populations were not...
- Orchid Wins First Certification for HLA Testing Using Luminex Platform.
- Press release article from: PR Newswire September 19, 2001 700+ words
...conduct commercial human leukocyte antigen (HLA) testing on the LabMAP(TM) platform...significantly reduce turn-around time for its HLA-DR tissue typing services both for single...testing and for donor recruitment drives. HLA typing is the first step for patients and...
- HLA-DQB1 alleles influence expression of DQ molecules in diabetes.
- Newspaper article from: Drug Week May 28, 2004 700+ words
...NewsRx.com & NewsRx.net) -- HLA-DQB1 alleles may influence the surface...expression of human leukocyte antigen (HLA) class II (DR and DQ) molecules on lymphomononuclear...matched to patients for age, sex, and HLA class II profile. The co-expression of...
Source: HighBeam Research, Antigenic Specificity of Infected Cells Defined.(Brief Article)