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Revaccination May Result in Reduced Antibody Response.(Brief Article)
2001 FEB 21 - (NewsRx.com & NewsRx.net) --
by Michelle Marble, staff medical writer -- According to a study from England, repeated immunization using meningococcal polysaccharide vaccines may actually reduce antibody response.
"Widespread use of meningococcal A and C polysaccharide (MACP) vaccines has raised concerns about induction of hyporesponsiveness to these polysaccharides," wrote R. Borrow and colleagues, Withington Hospital, in the journal Vaccine. "Immunological hyporesponsiveness to C polysaccharide has been clearly documented in infants, children, and adults but only limited data from Gambian children are available for A polysaccharide."
"We investigated whether a second dose of MACP, given six months after an initial dose affected the immunological response as measured by the serum bactericidal assay (SBA) and enzyme-linked immunosorbent assay (ELISA), to serogroup A meningococci in young adults (university students, n=36)," the authors said ("Reduced antibody response to revaccination with meningococcal serogroup A polysaccharide vaccine in adults," Vaccine, 2000;19(9-10):1129-1132).
They evaluated serogroup A SEA responses one month following the second dose of MACP (geometric mean titre (GMT) 103.6, 95% CI 45.6-235.1). Borrow et al. found that immune responses were approximately one third of the levels observed one month after the first dose was administered (GMT 281.9, 95% CI ...
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