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Angiogenesis, Fibrosis Associated with Mass Rim Enhancement on MRIs.(breast cancer)

Women's Health Weekly

| February 01, 2001 | Henderson, CW | COPYRIGHT 2001 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2001 FEB 1 -- (NewsRx.com) -- Diagnostic imaging, a powerful way to visualize the inner workings of the body, can be used in a new manner to evaluate breast cancers: The histological appearance of breast tumors tends to correlate with rim enhancement on magnetic resonance images (MRIs), researchers at Saga Medical School in Japan report in the journal Radiology.

Using MRI, investigators studied breast lesions from 35 women with invasive and non-invasive breast cancers. "In each patient, subtraction images of the dynamic contrast-enhanced study were obtained, and early and delayed rim enhancement and delayed internal enhancement was evaluated," said R. Matsubayashi et al.

Microvessel density at the peripheral and inner portions of the breast lesions was also measured and evaluated for histological appearance. These measurements, along with analyses for fibrosis and quantification of vascular endothelial growth factor (VEGF)and transforming growth factor (TGF)-beta 1, were correlated with the MRIs to determine any significant associations.

"Small cancer nests, a high ratio of peripheral-to-central microvessel density, peripheral VEGF expression, and a low ratio of peripheral-to-central fibrosis were correlated with early rim enhancement," reported researchers.

In contrast, delayed internal enhancement was more frequently associated with fibrosis and inflammation, Matsubayashi et al. ...

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