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Adoptive Transfer Reduces Gastritis Complications.(Brief Article)
2001 FEB 14 - (NewsRx.com & NewsRx.net) --
- by Michelle Marble, staff medical writer -- Adoptive transfer of splenocytes may effect cure of Helicobacter pylori without gastritis complications, suggest researchers.
"Vaccination suppresses Helicobacter pylori colonization but does not cure infection," wrote Kathryn A. Eaton and colleagues from Ohio State University. "Furthermore, post-vaccination gastritis, likely induced by enhanced host response to residual colonization, may exacerbate disease. The goal of this study was to determine if adoptive transfer of C57BL/6 splenocytes to C57BL/6scid/scid (severe combined immunodeficient [SCID]) mice cures infection without exacerbating gastritis."
Eaton et al. published their report in the journal Infection and Immunity ("Cure of Helicobacter pylori infection and resolution of gastritis by adoptive transfer of splenocytes in mice," Infect and Immun, February 2001;69(2):1025-1031.
"H. pylori-infected and uninfected C57BL/6 mice and SCID recipients of normal splenocytes were killed at intervals between five and 51 weeks after infection," continued the authors.
The researchers quantified levels of colonization of H. pylori and severity of gastritis in the experimental animals. Enzyme-linked immunosorbent assay was used to determine humoral immune responses. They determined cellular immune responses by evaluating delayed-type hypersensitivity response and by a proliferative response of cultured splenocytes to H. pylori sonicate.
"In infected C57BL/6 mice, gastritis developed gradually and bacterial colonization diminished but persisted throughout the experiment," wrote Eaton et al. "In contrast, ...
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Source: HighBeam Research, Adoptive Transfer Reduces Gastritis Complications.(Brief Article)