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Two Ligands Elicit Similar Cytotoxic T-Lymphocyte Responses.(Brief Article)
2001 FEB 14 - (NewsRx.com & NewsRx.net) --
- by Michelle Marble, staff medical writer -- According to a study from the United States, two CD28 ligands, B7-1 and B7-2, are functionally equivalent at stimulating plasmid DNA-vaccine-elicited responses in vivo.
"A co-stimulatory signal in addition to an antigen (Ag)-specific stimulus is required for optimal activation of T lymphocytes," stated S. Santra and colleagues, Harvard University, Boston, Massachusetts. "CD28, the primary positive costimulatory receptor on T cells, has two identified ligands, B7-1 and B7-2. Whether B7-1 and B7-2 have identical, overlapping, or distinct functions remains unresolved."
Santra et al. published the results of their study in the Journal of Immunology ("Functional equivalency of B7-1 and B7-2 for co-stimulating plasmid DNA vaccine-elicited CTL responses," J Immunol, 2000;165(12):6791-6795).
"In this study, we show that mice lacking B7-2 were unable to generate cytotoxic T lymphocyte (CTL) responses following immunization with a plasmid DNA vaccine," continued the authors.
However, they found that B7-2-deficient mice were capable of generating CTL responses following plasmid gp120 DNA vaccination if a plasmid vaccine expressing either B7-2 or B7-1 was ...
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Source: HighBeam Research, Two Ligands Elicit Similar Cytotoxic T-Lymphocyte Responses.(Brief...