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Beta Peptide Vaccine Prevents Memory Loss in Animal Model.(Brief Article)
2001 FEB 14 - (NewsRx.com & NewsRx.net) --
- by Michelle Marble, staff medical writer -- An amyloid-beta peptide (AB) vaccine was successful in two different mouse models of Alzheimer's disease, researchers in the United States reported.
"Vaccinations with AB can dramatically reduce amyloid deposition in a transgenic mouse model of Alzheimer's disease," wrote D. Morgan and colleagues, University of South Florida. "To determine if the vaccinations had deleterious or beneficial functional consequences, we tested eight months of A beta vaccination in a different transgenic model for Alzheimer's disease in which mice develop learning deficits as amyloid accumulates.
"Here we show that vaccination with A beta protects transgenic mice from the learning and age-related memory deficits that normally occur in this mouse model for Alzheimer's disease," continued the authors ("A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease," Nature, 2000;408(6815):982-985).
Mice were tested for potential deleterious effects of the vaccine. During this phase of testing, all vaccinated mice performed superbly on the radial-arm water-maze test, a test ...
- A-beta-peptide neurodegeneration in Alzheimer disease brain reviewed.
- Newspaper article from: Health & Medicine Week April 26, 2004 700+ words
...consequences of amyloid beta-peptide [1-42]-associated...neurodegeneration in the Alzheimer disease brain...stress and amyloid beta-peptide [A-beta] deposition...hallmarks of the Alzheimer disease [AD...Chemistry (Amyloid beta-peptide ...
- Beta Peptide Vaccine Prevents Memory Loss in Animal Model.(Alzheimer's disease)
- Newspaper article from: Pain & Central Nervous System Week Marble, Michelle February 17, 2001 700+ words
...mouse model for Alzheimer's disease...authors ("A beta peptide vaccination prevents...animal model of Alzheimer's disease...An amyloid-beta peptide (AB) vaccine was evaluated in Alzheimer's disease...
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- Magazine article from: BIOWORLD Today Leff, David N. April 30, 2002 700+ words
...this pyromaniacal metal has to do with Alzheimer's disease (AD) is the topic of a...the deceased did in fact suffer from Alzheimer's. Koh told BioWorld Today: "My...chronically to the transgenic mice with the Alzheimer precursor protein, and had a very beneficial...
- Nasal Amyloid-Beta Peptide Exposure Reduces Cerebral Damage.
- Newspaper article from: Immunotherapy Weekly December 6, 2000 700+ words
...cerebral deposition of [A beta] peptide, an early and essential feature of Alzheimer's disease...develop in the brains of Alzheimer's patients ("Nasal...administration of amyloid-beta peptide decreases cerebral...in a mouse model of Alzheimer's disease," Ann...
- Ethyl ether fraction of plant inhibits amyloid beta peptide-induced cell death.
- Newspaper article from: Pain & Central Nervous System Week March 10, 2003 700+ words
...induced by amyloid beta peptide. "Recently...been reported that Alzheimer's disease is...hippocampus. Amyloid beta peptide stimulates neuronal...protects amyloid beta peptide-induced cell...subject areas of Alzheimer's Disease, Neuroscience...
- Amyloid beta-peptide disrupts neural stem cell differentiation.
- Magazine article from: Stem Cell Week February 10, 2003 700+ words
...effects of amyloid beta-peptide on neural cell...mouse model of Alzheimer's disease...form of amyloid beta-peptide (Abeta) on the...neurogenesis by amyloid beta-peptide, and perturbed...in models of Alzheimer's disease...
- Catecholamines dissolve alpha-synuclein and A-beta peptide fibrils.
- Newspaper article from: Drug Week July 16, 2004 700+ words
...alpha-synuclein and A-beta peptide fibrils. According to recent...the aggregation of the A-beta peptide is associated with Alzheimer disease. Here we show that...alpha-synuclein and A-beta peptide generated in vitro...
- Response to human and rodent A-beta peptide is species-specific.
- Newspaper article from: Biotech Week November 10, 2004 700+ words
...human or rodent A-beta peptide and adjuvant LT(R192G...antibodies did not stain Alzheimer disease (AD) plaques...human versus rodent A beta peptide. Neurobiol Aging...major subject areas of Alzheimer Disease, Vaccine Development...
