AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Oral Vaccination with Mycobacterial Hsp65 Successful in Rat Model.(Brief Article)
2001 FEB 14 - (NewsRx.com & NewsRx.net) --
- by Michelle Marble, staff medical writer -- Oral mycobacterial heat-shock protein 65 (Hsp65) therapy for autoimmune diseases was evaluated by researchers in The Netherlands.
"Oral administration of antigen prior to disease induction has been shown to induce peripheral tolerance in several experimental autoimmune diseases," wrote P.M. Cobelens and colleagues, University of Utrecht. "However, the clinical benefit of pretreatment with antigens is limited. The aim of this study was to investigate whether adjuvant-induced arthritis (AIA) could be treated-by oral administration of mycobacterial heat-shock protein 65 (Hsp65) during ongoing disease."
Cobelens et al. published their study in the journal Arthritis and Rheumatism ("Treatment of adjuvant-induced arthritis by oral, administration of mycobacterial Hsp65 during disease," Arthritis Rheum, 2000;43(12):2694-2702).
The researchers induced AIA in Lewis rats by immunizing them with Mycobacterium tuberculosis in Freund's incomplete adjuvant. Eleven days after immunization, the rats were started on oral administration of Hsp65 in the presence or absence of soybean trypsin inhibitor (SBTI). Animals and their arthritis were monitored visually. Joint pathology was examined by X-rays.
"Oral treatment with Hsp65 during ongoing disease significantly reduced the activity of AIA," stated the authors. "However, treatment with Hsp65 was only successful when SBTI was co-administered to prevent breakdown of the Hsp65."
Radiological data from the study demonstrated a clear reduction of articular destruction in the joints of the experimental AIA animals as a result of the Hsp65/SBTI ...
- DNA virus-like particles elicit immune responses by oral administration.
- Newspaper article from: Vaccine Weekly May 12, 2004 700+ words
...immune responses by oral administration. According to...mucosal tissue by oral administration for the purpose...immune responses by oral administration. Gene Therapy...was prepared by Vaccine Weekly editors from staff...
- Pharmacokinetic properties of crocin (crocetin digentiobiose ester) following...
- Magazine article from: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology Xi, Liang Qian, Zhiyu Du, Peng Fu, Jian September 1, 2007 700+ words
...pharmacokinetic properties of crocin following oral administration in rats. After a single oral dose...through the intestinal tract following oral administration, (3) plasma crocetin concentrations...Crocetin; Pharmacokinetic properties; Oral administration; Rat Introduction Crocin ...
- RXi Pharmaceuticals Announces Publication in Nature of Positive Pre-clinical...
- Press release article from: Business Wire April 30, 2009 700+ words
...demonstrating that low dose (20 g/kg) oral administration of RNAi therapeutics resulted in...RXi Pharmaceuticals, noted, "Oral administration of RNAi therapeutics using this...as compared to controls, after oral administration of the respective GeRP-encapsulated...
- Antihypertensive peptides are present in aorta after oral administration of...
- Magazine article from: The Journal of Nutrition Masuda, Osamu; Nakamura, Yasunori; Takano, Toshiaki December 1, 1996 700+ words
...Peptides Are Present in Aorta after Oral Administration of Sour Milk Containing These Peptides...antihypertensive effects after a single oral administration to spontaneously hypertensive rats...about their action in vivo after oral administration. Recently, we found that the ...
- European Patent Office Grants Patent for Oral Administration of GlycoGenesys,...
- Press release article from: Business Wire October 5, 2004 700+ words
...applications covering both the IV and oral administration of GCS-100 in the United States...slowly progressing cancers where oral administration might be favored by physicians and...Inhibiting Cancer Metastasis by Oral Administration of Soluble Modified Citrus Pectin...
- ZIOPHARM Presents Darinaparsin Molecular Mechanism of Action and Preliminary...
- Press release article from: Business Wire October 23, 2008 700+ words
...preliminary data from Phase I studies with oral administration at the 20th EORTC-NCI-AACR Symposium...ongoing. The serum level obtained by oral administration compared to intravenous administration...lymphomas and in Phase I study with oral administration. Darinaparsin has been well ...
- ImmuneRegen BioSciences Confirms Homspera's Therapeutic Anti-Influenza Effect...
- Press release article from: PR Newswire July 29, 2009 700+ words
...agonist Homspera is both active on oral administration and provides therapeutic effects...studies in rats had revealed the oral administration of Homspera resulted in measurable...important is the demonstration that oral administration of Homspera results in therapeutic...
- Oral administration of lactoferrin increases hemoglobin and total serum iron in...
- Magazine article from: Alternative Medicine Review Paesano, R. Torcia, F. Berlutti, F. December 1, 2006 700+ words
...different trimesters of pregnancy were enrolled in a trial of oral administration of ferrous sulfate (520 mg once a day) or 30% iron...31 weeks of pregnancy. In contrast, after 30 d of oral administration of bLf, hemoglobin and total serum iron values increased...
