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DNA Immunization Induces Protective Immunity Against Plasmodium falciparum.(Brief Article)
2001 FEB 14 - (NewsRx.com & NewsRx.net) --
- by Michelle Marble, staff medical writer -- Can a DNA vaccine against malaria work?
Researchers in France say yes.
"DNA-based immunization of mice by Plasmodium falciparum liver-stage antigen 3 (PfLSA3), a novel highly conserved P. falciparum pre-erythrocytic antigen, was evaluated," wrote Jean-Pierre Sauzet and colleagues from the Institut Pasteur.
Sauzet et al. published their study in the journal Infection and Immunity ("DNA immunization by Plasmodium falciparum liver-stage antigen 3 induces protection against Plasmodium yoelii sporozoite challenge," Infect and Immun, February 2001;69(2):1202-1206).
Mice were immunized with DNA encoding PfLSA3. Immunized animals developed a Th1 dominant immune response, which was typified by high gamma interferon T-cell responses and a predominance of immunoglobulin G2a. When evaluated, the researchers noted that the response was reactive to each of three recombinant proteins spanning the molecule. Immunized mice resisted challenge with P. yoelii.
"We have exploited the immunological ...
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