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Systemic and Mucosal Immunizations Induce Protective Immune Responses.(Brief Article)
2001 FEB 14 - (NewsRx.com & NewsRx.net) --
- by Michelle Marble, staff medical writer -- Vaccines against Streptococcus pyogenes have been evaluated in an animal model.
"The purpose of this study was to examine the suitability of fibronectin-binding protein FBP54 as a putative vaccine for Streptococcus pyogenes infections," wrote Shigetada Kawabata and colleagues from Osaka University. "When the distribution of the fbp54 gene among the clinical isolates representing various M serotypes was tested by PCR [polymerase chain reaction] and Southern blot assays, it was found that all of the strains possess this gene."
Kawabata et al. published their study in the journal Infection and Immunity, ("Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge in mice," Infect and Immun, February 2001;69(2):924-930).
"Furthermore, a significant increase in immunoglobulin G (IgG) antibody titers against FBP54 was observed in sera from patients with S. pyogenes infections compared with those from healthy volunteers (P
The researchers immunized groups of mice with FBP54 given subcutaneously, orally, or nasally. An enzyme-linked immunosorbent assay (ELISA) was used to evaluated immune responses in the vaccinated animals.
The assay revealed ...
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