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Multidrug-Resistance On the Rise in the United States.(Brief Article)
2001 FEB 14 - (NewsRx.com & NewsRx.net) --
- by Michelle Marble, staff medical writer -- According to recent research from the U.S. Centers for Disease Control and Prevention (CDC), multidrug-resistant strains of Streptococcus pneumoniae are circulating in the United States.
"The emergence of drug-resistant strains of bacteria has complicated treatment decisions and may lead to treatment failures," wrote C.G. Whitney and colleagues, CDC, Atlanta, Georgia. "We examined data on invasive pneumococcal disease in patients identified from 1995 to 1998 in the Active Bacterial Core Surveillance program of the CDC. Pneumococci that had a high level of resistance or had intermediate resistance according to the definitions of the National Committee for Clinical Laboratory Standards were defined as 'resistant' for this analysis."
Whitney et al. published their study in the New England Journal of Medicine ("Increasing prevalence of multidrug-resistant Streptococcus pneumoniae in the United States," N Engl J Med, 2000;343(26):1917-1924).
"During 1998, 4013 cases of invasive S. pneumoniae disease were reported (23 cases per 100,000 population); isolates were available for 3475 (87%)," wrote the authors. "Overall, 24% of isolates from 1998 were resistant to penicillin. The proportion of isolates that were resistant to penicillin was highest in Georgia (33%) and Tennessee (35%), in children under five years of age (32% vs. 21% for persons five or more years of age), and in whites (26% vs. 22% for blacks)."
Whitney et al. said that the penicillin-resistant isolates often exhibited a high level of resistance to other antimicrobial agents when compared to susceptible isolates. They noted that the serotypes included in the 7-valent conjugate and ...
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Source: HighBeam Research, Multidrug-Resistance On the Rise in the United States.(Brief Article)