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Anti-Glycosylphosphatidylinositol Antibodies are Protective.(Brief Article)
2001 FEB 14 - (NewsRx.com & NewsRx.net) --
- by Michelle Marble, staff medical writer -- Study results indicate anti-glycosylphosphatidylinositols (GPI) antibodies protect against clinical signs of infection.
"Induction of proinflammatory cytokine responses by GPIs of intra-erythrocytic Plasmodium falciparum is believed to contribute to malaria pathogenesis," stated R.S. Naik and colleagues, Georgetown University. "In this study, we purified the GPIs of P. falciparum to homogeneity and determined their structures by biochemical degradations and mass spectrometry."
Naik et al. published the results of their study in the Journal of Experimental Medicine ("Glycosylphosphatidylinositol anchors of Plasmodium falciparum: Molecular characterization and naturally elicited antibody response that may provide immunity to malaria pathogenesis," J Exp Med, 2000;192(11):1563-1575).
"The parasite GPIs differ from those of the host in that they contain palmitic (major) and myristic (minor) acids at C-2 of inositol, predominantly C18:0 and C18:1 at sn-1 and sn-2, respectively, and do not contain additional phosphoethanolamine substitution in their core glycan structures," stated the authors.
Naik's team found that purified parasite GPIs induced tumor necrosis factor (alpha) release from host macrophages.
A new finding of the study was that adults who are resistant to clinical malaria have high ...
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...sub.2]-glycoprotein I (anti-[beta.sub.2]GPI) antibodies, IgG and IgM antiprothrombin antibodies. Homocysteinaemia...with thrombosis in SLE. (2 3) Anti-[beta.sub.2]GPI antibodies do not add any information to LAC, and anti-[beta...
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Source: HighBeam Research, Anti-Glycosylphosphatidylinositol Antibodies are Protective.(Brief...