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Anti-Idiotypic Humoral Responses Induced by T-Cell Vaccination.(Brief Article)
2001 FEB 14 - (NewsRx.com & NewsRx.net) --
- by Michelle Marble, staff medical writer -- Humans can respond to T-cell vaccination with anti-idiotypic antibody (Ab) responses, neurologists report.
"Immunization with irradiated autoreactive T cells (T-cell vaccination) induces anti-idiotypic T-cell responses that preferentially recognize complementarity-determining region 3 sequences, contributing to clonal depletion of autoreactive T cells," wrote J. Hong and colleagues, Baylor College of Medicine, Houston, Texas. "However, it remains unknown whether T-cell vaccination elicits anti-idiotypic humoral responses and whether the anti-idiotypic Abs play a similar role in the regulatory mechanism induced by T-cell vaccination. In this study we examined the occurrence, the reactivity pattern, and the regulatory role of anti-idiotypic Abs elicited by T-cell vaccination in patients with multiple sclerosis."
Hong et al. published their study in the Journal of Immunology ("Reactivity and regulatory properties of human anti-idiotypic antibodies induced by T-cell vaccination," J Immunol, 2000;165(12):6858-6864).
Documented for the first time, the researchers demonstrated that B cells producing anti-idiotypic Abs could be isolated from vaccinated patients. They selected Epstein-Barr virus (EBV)-transformed B-cell lines with specific reactivity to a 20-mer TCR peptide incorporating a common ...
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Source: HighBeam Research, Anti-Idiotypic Humoral Responses Induced by T-Cell Vaccination.(Brief...