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Breast Density Changes as HRT Starts and Stops.(hormone replacement therapy)
2001 JAN 25 - (NewsRx.com) -- Changes in breast density associated with hormone replacement therapy are dynamic, increasing with initiation, and decreasing when therapy is discontinued, according to an article in the January 10, 2001, issue of the Journal of the American Medical Association.
Carolyn M. Rutter, PhD, and colleagues with Group Health Cooperative of Puget Sound and the University of Washington, Seattle, examined the effects of initiation, discontinuation, and continued use of hormone replacement therapy (HRT) on breast density in postmenopausal women. They studied 5,212 naturally postmenopausal women between the ages 40 to 96 who were enrolled in a large health maintenance organization in western Washington State. Each of the women had two screening mammograms between 1996 and 1998.
According to background information cited in the study, initiation of HRT has been shown to increase breast density. Increased density reduces the accuracy of screening mammography. HRT has been directly associated with decreases in both sensitivity and specificity of mammography, which is likely a result of corresponding increases in density. Studies have also associated increased density with increased risk of breast cancer. Although the effect of initiating HRT on breast density has been well studied, the effects of continuing and discontinuing HRT have not been systematically examined.
The authors defined HRT to include estrogens alone and estrogens in combination with a progestin, delivered orally or by a patch. They compared breast density among women who were divided into groups based on patterns of HRT use: 1) nonusers were those who did not use HRT before either mammogram; 2) discontinuers were those who used HRT before their first mammogram, but not before their second mammogram; 3) initiators were those who did not use HRT before their first mammogram, but began using HRT before their second mammogram; 4) continuing users were those who ...
- Breast Density Predicts Failure of Mammography.
- Magazine article from: Family Practice News MOON, MARY ANN May 15, 2000 700+ words
...sharply declined as breast density increased, from about...association between breast density and failure of mammography...Efforts to reduce breast density at the time of mammography...Women Who Are Taking HRT BETHESDA, MD...
- Red clover isoflavones and breast density in women.(Research News)
- Magazine article from: Townsend Letter for Doctors and Patients Hudson, Tori October 1, 2004 700+ words
...has been the increase in mammographic breast density within the first year of taking HRT. G'ven that breast density on mammograms is a risk factor for breast...has added to the concern about taking HRT. This study on red clover isoflavones...
- Menopause Study Shows Remifemin(R) Black Cohosh Is Safer Than HRT.
- Press release article from: PR Newswire March 1, 2007 700+ words
...replacement therapy (HRT) with major risk...thickening, increased breast density, and breast cell...Women with high breast density have a 5-fold...with low density. HRT has been shown to increase breast density by 30-50 percent...
- HRT Use Seldom Affects Mammogram Readings.
- Magazine article from: OB GYN News JOHNSON, KATE May 1, 2001 700+ words
...hormone replacement therapy (HRT) on a woman's mammogram readings...previous studies have shown that [HRT-related] increases in breast density were leading to patients having...America, 7% of 880 women on HRT, and 6% of 2,342 women not...
- Mammography Readings Largely Unaffected by HRT.(Brief Article)
- Magazine article from: Family Practice News JOHNSON, KATE March 15, 2001 700+ words
...hormone replacement therapy (HRT) on mammogram readings has found...previous studies have shown that [HRT-related] increases in breast density were leading to patients having...America, 7% of 880 women on HRT, and 6% of 2,342 women not...
- Do painful breasts signal HRT cancer risk?(CANCER NEWSBRIEFS)(hormone...
- Magazine article from: Health News January 1, 2007 700+ words
...replacement therapy (HRT) well into their 70s...symptoms may abate, HRT increases the likelihood...breasts. Changes in breast density are of concern, as dense...randomly assigned either to HRT or placebo. The connection...9 percent increase in breast density compared with a ...
- HRT Reduces Sensitivity of Mammograms.(hormone replacement therapy)
- Magazine article from: Family Practice News Moon, Mary Ann March 1, 2000 700+ words
...23 cancers that were missed in HRT users would have been detected...sensitivity is that women using HRT have a greater breast density, which is known to reduce mammographic...Women who are considering starting HRT should be informed about its potential...
- HRT Interferes With Screening.
- Magazine article from: OB GYN News Moon, Mary Ann March 1, 2000 700+ words
...with 74.7% in women not taking HRT, after the data were adjusted...23 cancers that were missed in HRT users would have been detected...sensitivity is that women using HRT have a greater breast density, which is known to reduce mammographic...
- Reassurance on HRT cancer risk.
- Magazine article from: GP December 21, 2001 700+ words
...should not drag in everyone on HRT. I still see many benefits of HRT, and it definitely increases...cited 'clear' evidence to show HRT increased density of breast...that oestrogen alone increases breast density less than combined treatments...
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- News wire article from: Chemical Business Newsbase March 1, 2007 700+ words
...linked hormone replacement therapy (HRT) with major risk indicators for breast...including endometrial thickening, increased breast density, and breast cell proliferation. A...showed any increase in mammographic breast density. Furthermore, there was no increase...
Source: HighBeam Research, Breast Density Changes as HRT Starts and Stops.(hormone replacement...