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Vicious Cycle Drives Calcium and Peptide to Stimulate Metastatic Bone Cancers.(PTh-related peptide)
2001 JAN 25 - (NewsRx.com) -- by Sonia Bell-Nichols, staff medical writer -- New research supports the theory that breast cancer cells secrete a peptide that encourages metastatic bone tissues to express substances that induce the secretion of additional peptide.
The peptide is called PTH-related peptide (PTHrP).
The process is a vicious cycle, study authors said.
Breast cancer cells and normal cells express calcium receptors. Extracellular calcium stimulates those receptors to secrete PTHrP, which in turn cause cancerous bone tissues to secrete transforming growth factor-beta.
"Secretion of PTHrP from breast cancer cells is thought to play a key role in osteolytic metastases and is increased by transforming growth factor-beta (TGF-beta), which is released from resorbed bone," commented J.L. Sanders and colleagues at Brigham and Women's Hospital in Boston, Massachusetts.
Research of two breast cancer cell lines revealed that both express calcium receptor proteins. Further addition of calcium to the cells resulted in the secretion of approximately twice as much PTHrP. Such secretion depended on the amount of calcium and two complementary compounds, ...
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- Press release article from: Business Wire June 20, 2007 700+ words
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- Press release article from: Business Wire November 11, 2008 700+ words
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Source: HighBeam Research, Vicious Cycle Drives Calcium and Peptide to Stimulate Metastatic Bone...