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Fibroblast Growth Factor and Its Receptors Common to Ovarian Tumors.
2001 JAN 18 - (NewsRx.com) -- Fibroblast growth factor (FGF)-8, a growth factor known for its mitogenic properties, could be a marker for ovarian cancer due to its relatively common expression on ovarian cancer cells, according to a new study.
Researchers in Finland at the University of Turku have identified several FGF-8 isoforms on human ovarian tumors and cells grown in culture. In addition, they have found that several FGF receptors are commonly found on a number of types of normal ovarian cells as well as cancerous cells.
E. Valve and associates at the MediCity Research Lab in Turku examined five normal human ovaries and 51 ovarian tumors for differences in FGF-8 isoform and FGF receptor expression.
"FGF-8 isoform B was expressed in all ovarian tumors and in all seven ovarian-cancer cell lines studied," reported Valve et al.
Furthermore, researchers identified FGF isoform A in nine of the tumors, but no FGF mRNA in any of the normal ovaries, based on reverse-transcriptase polymerase chain reaction.
Immunohistochemical staining was also performed. "In general, the increased intensity of FGF-8 staining was associated with loss of differentiation within the tumors (Bowker's test, P=0.37)," Valve et al. said.
Researchers also detected FGF receptors on ovarian cells of different ...
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Source: HighBeam Research, Fibroblast Growth Factor and Its Receptors Common to Ovarian Tumors.