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Intrathecal Alfentanil Effective Without Bupivacaine for Labor Pain.
2001 JAN 18 - (NewsRx.com) -- Alfentanil alone appears to be sufficient for initiating combined spinal-epidural analgesia for labor pain, researchers suggest.
They say supplementation with bupivacaine is unnecessary and possibly detrimental to the quality of pain relief.
"Combined spinal-epidural (CSE) for analgesia in labor is widely used as a method of providing pain relief while minimizing motor blockade," D.A. Hill and colleagues at Ulster Hospital, Ireland, explained in the journal Anaesthesia.
Hill et al. evaluated the quality of pain relief and the extent of motor blockade produced by using 0.25 mg of intrathecal alfentanil as the spinal portion of combined spinal-epidural analgesia. They compared these effects with those produced by the same quantity of alfentanil combined with 2.5 mg of bupivacaine, using 30 women randomly allocated to one of the treatment modalities ("Intrathecal alfentanil with and without bupivacaine for analgesia in labour," Anaesthesia, 2000;55(11):1116--l121).
They found that, while all women reported satisfactory pain relief, the quality of analgesia was significantly (P=0.003) greater for those women treated with alfentanil alone than for women administered a combination of alfentanil and bupivacaine. In addition, the time to onset of analgesia was significantly (P[less than]0.05) longer for women in the alfentanil-bupivacaine cohort, requiring an average of 55 minutes for the onset of pain relief as opposed to 40 minutes for their counterparts.
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Source: HighBeam Research, Intrathecal Alfentanil Effective Without Bupivacaine for Labor Pain.