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Cell Membrane Phospholipids Can Affect Chances of Insulin Dysfunction in Obese Patients.
2001 JAN 18 - (NewsRx.com) -- Elevated levels of a number of different cell membrane components can put both diabetic and otherwise healthy obese women at a higher risk for hyperinsulinemia and insulin resistance, researchers in France report.
"The cell functions involved in the action of insulin-receptor binding, enzyme and transporter activities are controlled by membrane properties," explained M. Donner and colleagues at the Centre Hospitalier Universitaire de Brabois.
Having shown in previous studies that the concentration of the phospholipid sphingomyelin in red blood cells is correlated with increased insulin levels and insulin resistance in obese women, Dormer et al. examined the relationships between similar phospholipids in the membranes of adipocytes (fat cells) and insulin dysfunction in their current study ("Adipocyte and erythrocyte plasma membrane phospholipid composition and hyperinsulinemia: A study in nondiabetic and diabetic obese women," International Journal of Obesity, December 2000;24(12):1600-1607).
They found that the adipocyte membrane concentrations of sphingomyelin were positively correlated with fasting plasma insulin (FPI) concentration and insulin resistance as measured by homeostasis model assessment (HOMA). In addition, the levels of other structural phospholipids in the fat ...
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