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Patient Age Joins Tumor Size and Angiogenesis in Predicting Metastasis.(breast cancer )
2001 JAN 18 - (NewsRx.com) -- A study comparing breast cancer patients of different ages has shown that age, in addition to tumor size, angiogenesis, and other tumor-related factors, is an independent variable for the risk of metastasis in adjoining lymph nodes.
The study defined three age groups - patients under the age of 50, patients between the ages of 51 and 70, and patients older than 70 years old - in an attempt to correlate age with the risk of spreading cancer in patients with pT1 breast carcinomas.
The tumors and records of more than 1,000 breast cancer patients were selected for preliminary analysis in the retrospective study. Ultimately, 375 women were identified as having node positive cancers. Those women were then delegated to the three age-group classifications.
A team of researchers from the University of Turin in Italy assessed tumor characteristics such as grade, vascular invasion around the tumor, angiogenesis, and multicentricity. They also looked for hormonal factors such as estrogen and progesterone receptors and genetic markers (p53 and c-erbB2) that are sometimes thought to be associated with breast cancer and the propensity for metastasis.
"Univariate analysis showed that nodal positivity was significantly correlated with large tumor size ([greater than] 10 mm), vascular invasion, grade 2-3, multicentricity, and high angiogenesis ([greater than] 100 microvessels/x20 high power frame)," remarked R. Arisio et al.
In contrast, Arisio et al. could find no link between node positivity and either hormonal receptors or the two genetic markers p53 and c-erbB2.
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