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Combination of Drugs Deadly for HIV+ Pregnant Women.(ddI and d4T)
2001 JAN 18 - (NewsRx.com) -- Three pregnant women infected with HIV recently died from a severe side effect caused by taking two AIDS drugs together, the U.S. government said on January 5, 2001, in a warning to pregnant women to try to avoid a combination of the drugs ddI and d4T.
Four other pregnant women suffered nonfatal cases of lactic acidosis, an emergency condition in which acid builds up in the body and can seriously damage the liver or pancreas.
A class of older AIDS medicines called nucleoside analogs comes with warnings that such drugs occasionally cause lactic acidosis, and that women seem to be at higher risk than men. But the recent deaths prompted the U.S. Food and Drug Administration to issue a special warning for pregnant women. Officials couldn't say why the problem seemed to suddenly arise, although it has ...
- Lactic Acidosis With HIV Drugs Reported.
- Magazine article from: OB GYN News Wang, Jennifer M. February 15, 2001 700+ words
...cases at fatal lactic acidosis have been reported in pregnant women using stavudine...with and without lactic acidosis or hepatic failure...been reported in pregnant women taking only stavudine...didanosine. Lactic acidosis is a well-described...
- Lactic Acidosis in Pregnancy.(Brief Article)
- Magazine article from: Family Practice News February 1, 2001 700+ words
Three cases of fatal lactic acidosis occurred in pregnant women who used stavudine and didanosine with...should be monitored closely for signs of lactic acidosis and liver damage. Lactic acidosis is a well-described complication of...
- Acute onset lactic acidosis and pancreatitis in the third trimester of...
- Magazine article from: Sexually Transmitted Infections Sarner, L. Fakoya, A. February 1, 2002 700+ words
...pregnancy who presented with acute lactic acidosis and acute pancreatitis, respectively...risk of these presentations in pregnant women taking antiretrovirals, and...embolism. A diagnosis of severe lactic acidosis was made although the cause...
- Lactic Acidosis in Africans Receiving HAART.(HIV positive adults receiving...
- Newspaper article from: AIDS Alert Kemper, Carol A. September 1, 2007 700+ words
Lactic Acidosis in Africans Receiving HAART By Carol...Karstaedt AS. A high incidence of lactic acidosis and symptomatic hyperlactatemia...elevated lactic acid levels and lactic acidosis, presumably related to mitochondrial...
- Metformin-associated lactic acidosis in a patient with vertebral artery...
- Magazine article from: Southern Medical Journal Packer, Clifford D. October 1, 2006 700+ words
...has been implicated as a cause of lactic acidosis, usually in a setting of renal failure...2) there are very few reports of lactic acidosis (blood lactate >5 mEq/L...and normal renal function developed lactic acidosis in the absence of other risk factors...
- d4T and lactic acidosis with neuromuscular weakness: FDA warning.(Brief Article)
- Newspaper article from: AIDS Treatment News March 8, 2002 700+ words
...label to describe the occurrence of lactic acidosis and neuromuscular toxicity in patients...Barre syndrome in association with lactic acidosis were reported to the FDA's Adverse...symptoms that might have been due to lactic acidosis, such as abdominal pain, nausea...
- Lactic acidosis during nucleoside antiretroviral HIV therapy.(Letters to the...
- Magazine article from: Southern Medical Journal Khater, Fares J. Youssef, Souad Iskandar, Said B. Myers, James W. Moorman, Jonathan P. February 1, 2004 700+ words
...increasingly recognized as a cause of lactic acidosis. We report a case of fatal NRTI-induced lactic acidosis that occurred 4 months after stavudine...was treated for pancreatitis and lactic acidosis but rapidly became disoriented...
- Reports outline lactic acidosis therapy study findings from Ernst-Moritz-Arndt...
- Newspaper article from: Diabetes Week August 25, 2008 700+ words
...determinants for metformin-associated lactic acidosis and metformin utilization in the study...complication of metformin-associated lactic acidosis are frequently disregarded. Our first...Greifswald, Germany report (see also Lactic Acidosis Therapy). "Our second aim was to...
- Reports summarize lactic acidosis study results from Korea University,...
- Newspaper article from: Blood Weekly December 4, 2008 700+ words
...compare the prognostic abilities of lactic acidosis and hyperlactatemia and determine...arterial pH. Survival curves for lactic acidosis and severe hyperlactatemia were analysed...in septic patients. Patients with lactic acidosis had significantly higher inhospital...
- Recovery from ph 6.38: Lactic acidosis complicated by hypothermia. (Case...
- Magazine article from: Emergency Medicine Journal Ahmad, S. Beckett, M. March 1, 2002 700+ words
...uncommon. A case of metformin induced lactic acidosis is described where the presenting...confirmed our suspicion of type B lactic acidosis secondary to metformin exacerbated...butyrate, acetoacetate, lactate), lactic acidosis (lactate), uraemic acidosis (phosphate...
Source: HighBeam Research, Combination of Drugs Deadly for HIV+ Pregnant Women.(ddI and d4T)