AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Serotype G Chiamydia Strain Strongly Associated with Disease Development.(cervical squamous cell carcinoma )
2001 JAN 18 - (NewsRx.com) -- Women with the sexually transmitted infection Chlamydia trachomatis are at increased risk of developing cervical squamous cell carcinoma (SCC), and the risk is highest when the infection is serotype G, according to an article in the January 3, 2001, issue of the Journal of the American Medical Association (JAMA).
Tarja Anttila, MD, of the National Public Health Institute, Oulu, Finland, and Jorma Paavonen, MD, of the University of Helsinki, and colleagues studied the association between exposure to different Chlamydia trachomatis serotypes and subsequent development of cervical SCC. They conducted a longitudinal, nested case-control study among 530,000 women who provided samples to serum banks in Finland, Norway, and Sweden.
The data files were linked to respective national cancer registries. The study focused on 128 women who developed invasive cervical SCC at least 12 months following serum donation. Each case had three matched controls.
According to the American Medical Association Encyclopedia of Medicine, chlamydiae are a group of microorganisms, intermediate in size between bacteria and viruses, that cause various infectious diseases in humans and animals. Like viruses, they can multiply only by first invading the cells of another life-form; otherwise, they behave more like bacteria than viruses, and are susceptible to treatment with antibiotic drugs. Chlamydia trachomatis and Chlamydia pneumoniae are the two main species of chlamydiae that cause disease in humans. Different strains of C. trachomatis are responsible for various genital, eye, and lymph node infections.
According to background information cited in the study, human papillomavirus (HPV) infection is the leading cause of cervical neoplasia. Additional risk factors include other sexually transmitted infections (STIs) and smoking. Epidemiologic studies suggest that Chlamydia trachomatis infection also confers increased risk for cervical SCC, but whether the risk is serotype-specific has been unknown.
The authors measured serum IgG antibodies to C. trachomatis and Chlamydia pneumoniae. They looked at the risk for development of cervical SCC by IgG antibodies to ten different C. trachomatis serotypes, adjusted for antibodies to HPV types 16, 18, and 33, and for serum cotinine levels to measure tobacco use.
"Of specific C. trachomatis serotypes, serotype G was most strongly associated with SCC [6.6 times increased risk]. Other serotypes associated with SCC were I [3.8 times increased risk] and D [2.7 times increased risk]," the authors wrote. "Exposure to more than one serotype increased the risk for cervical SCC."
- New findings from Zhejiang University, Medical Department in the area of...
- Newspaper article from: Cancer Weekly October 6, 2009 700+ words
...nucleotide polymorphisms might be associated with all increased risk of cervical cancer development among Chinese...AGA (Arg) allele is a genetic risk factor of cervical SCC, and the increased risk is probably not caused by increasing host susceptibility...
- Serotype G Chlamydia Strain Strongly Associated with Disease Development.
- Newspaper article from: Cancer Weekly January 16, 2001 700+ words
...infection also confers increased risk for cervical SCC, but whether the risk...were I [3.8 times increased risk] and D [2.7 times increased risk]," the authors wrote...increased the risk for cervical SCC." The authors believe...
- Updated Recommendation from the Advisory Committee on Immunization Practices...
- Magazine article from: MMWR. Morbidity and Mortality Weekly Report Anonymous September 25, 2009 700+ words
...and for persons aged 2-55 years at increased risk for meningococcal disease (1-3...Sanofi Pasteur) who are at prolonged increased risk for meningococcal disease should be...gt;7 years and are at pro longed increased risk should be revaccinated 5 years after...
- Long-Term ERT Associated With Increased Risk Of Ovarian Cancer Death Among...
- Magazine article from: Women's Health Weekly April 5, 2001 700+ words
...more were found to be at substantially increased risk of fatal ovarian cancer that persisted...estrogen use is associated with an increased risk of endometrial and breast cancer...10 or more years was associated with increased risk of ovarian cancer mortality that persisted...
- Growing evidence for increased risk of breast, skin cancers among cabin crew.
- Newspaper article from: Health & Medicine Week November 10, 2003 700+ words
...Airplane cabin crew seem to be at increased risk of breast and skin cancers, suggests...factors alone don't account for the increased risk of malignant melanoma. Another Icelandic...while female flight attendants had an increased risk of breast cancer, this was not statistically...
- Standard of proof for increased risk of disease or injury.
- Magazine article from: Defense Counsel Journal Wiechmann, Eric W. January 1, 1994 700+ words
CLAIMS for the increased risk of future disease often are predicated...carcinogen and, as a result, has an increased risk of contracting some form of cancer...a present claim for enhanced or increased risk of cancer and were forced to wait...
- Increased Risk of Breast Cancer with Estrogen-Progestin Therapy.(Clinical...
- Newspaper article from: Clinical Oncology Alert April 1, 2003 700+ words
Increased Risk of Breast Cancer with Estrogen-Progestin...statistics, which amounted to an increased risk of 1.92 with 4-10 years of postmenopausal...This produced a calculated overall increased risk of 1.09 that almost but not quite...
- Migraine tied to increased risk of CV complications: two large studies yield...
- Magazine article from: Internal Medicine News Sullivan, Michele G. October 15, 2009 700+ words
...migraine with aura was associated with an increased risk of cardiovascular death in a large...migraineurs--a significant 60% increased risk. Rates of stroke were higher in those...had a heart attack, but they had no increased risk of stroke. The findings may help physicians...
