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Scientists Associate Cancer with Growth Factor in Serum of Pre-Menopausal Women.(insulin-like growth factor )
2001 JAN 18 - (NewsRx.com) -- New research indicates that a hormone called insulin-like growth factor (IGF)-I is observed more often in pre-menopausal women with breast cancer than in same-aged women without breast cancer.
The new research was reported in the International Journal of Cancer.
"Insulin-like growth factor I is a systemic hormone with potent mitogenic and anti-apoptotic properties, which could influence the proliferative behavior of normal breast cells," Paolo Toniolo of New York University's School of Medicine and colleagues stated.
Mitogens are agents that induce cells to undergo mitosis, or reproduction. Sometimes the process can go awry and cancer cells are formed.
In a prospective study of previously stored serum samples from 115 pre- and post-menopausal women, researchers determined premenopausal women with breast cancer to have higher serum IGF-I levels than matched controls.
"The risk of breast cancer increased with increasing serum concentrations of IGF-I in premenopausal women," reported Toniolo et al. ("Serum insulin-like growth factor-I and breast cancer," Int J Cancer, 2000;88(5):828-832).
Researchers did not detect higher levels of IGF-I nor similar ...
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