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Emerging Poxvirus May Have Developed from Brazilian Smallpox Vaccine.(Brief Article)
2001 JAN 31 - (NewsRx.com & NewsRx.net) -- An emerging poxvirus in cattle and humans in Brazil may have developed from the Brazilian smallpox vaccine, researchers in that country say.
"The biological properties of poxvirus isolates from skin lesions on dairy cows and milkers during recent exanthem episodes in Cantagalo County, Rio de Janeiro State, Brazil, were more like vaccinia virus (VV) than cowpox virus," wrote C.R.A. Damaso and colleagues, Institute Biofis Carlos Chagas Filho, Rio de Janeiro. "Polymerase chain reaction (PCR) amplification of the hemagglutinin (HA) gene substantiated the isolate classification as an Old World orthopoxvirus, and alignment of the HA sequences with those of other orthopoxviruses indicated that all the isolates represented a single strain of VV, which we have designated Cantagalo virus (CTGV)."
Damaso et al. published their study in the journal Virology ("An emergent poxvirus from humans and cattle in Rio de Janeiro State: Cantagalo virus may derive from Brazilian smallpox vaccine," Virol, 2000;277(2):439-449).
The researchers evaluated HA sequences from the Brazilian smallpox vaccine strain (VV-IOC) which was used over 20 years ago and compared it to the CTGV. Results of the comparison showed a 98.2% identity. Further phylogeny inference ...
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