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Autoantigen-Pulsed Dendritic Cells Induces Tolerance in Experimental Model.(Brief Article)
2001 JAN 31 - (NewsRx.com & NewsRx.net) -- An autoantigen-pulsed dendritic cell (DC) vaccine induced tolerance against experimental allergic encephalomyelitis (EAE) in a rat model, researchers in Sweden report.
"DC can modulate the nature of immune responses in a stimulatory or tolerogenic fashion," wrote Y.M. Huang and colleagues, Huddinge University Hospital, Karolinska Institute. "Great attention has been given to the induction of immunity to tumor and infection. In this study, bone marrow-derived DC from healthy Lewis rats were pulsed in vitro with encephalitogenic myelin basic protein peptide 68-86 (MBP 68-86), and injected subcutaneously (1x10(6)/rat) into normal Lewis rats."
Huang et al. published their study in the journal Clinical and Experimental Immunology ("Autoantigen-pulsed dendritic cells induce tolerance to experimental allergic encephalomyelitis (EAE) in Lewis rats," Clin Exp Immunol, December 2000;122(3):437-444).
The rats pretreated in this manner were observed for up to four weeks, reported the researchers. When no clinical signs of EAE occurred during this time from the pretreatment, the rats (and a control group) were then immunized with MBP 68-86 and Freund's complete adjuvant.
"The pretreated rats failed to develop clinical EAE," wrote Huang et al. "This tolerance was associated with augmented proliferative responses, interferon-gamma secretion, inducible nitric oxide synthase (iNOS) expression, and nitric oxide (NO) production."
According to the researchers, there was an increase in frequency ...
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Source: HighBeam Research, Autoantigen-Pulsed Dendritic Cells Induces Tolerance in Experimental...