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2001 JAN 24 - (NewsRx.com & NewsRx.net) -- Researchers in Israel have demonstrated that young seropositive infants who receive concomitant vaccinations for hepatitis A and diphtheria-tetanus-pertussis-polio/Haemophilus influenzae b vaccines are sufficiently primed to develop protection against hepatitis A virus (HAV).
The presence of anti-hepatitis A antibodies tends to interfere with immunological responses to hepatitis A vaccine. This situation is true of infants of mothers who receive a transfer of hepatitis A maternal antibodies at birth.
Three hundred young infants between six and 10 weeks old, born of seropositive and seronegative mothers, received high-dose vaccines of hepatitis A at two-month intervals beginning at the second month following birth and again at four and six months. The hepatitis A vaccinations were accompanied by doses of diphtheria-tetanus toxoid-acellular-inactivated poliovirus/Haemophilus influenzae b vaccine.
An additional booster dose of hepatitis A vaccine was administered at the twelfth month following birth to initially seropositive infants.
One hundred more one-year-old infants not previously vaccinated for hepatitis A also received a dose of the vaccine. All infants were followed in the months following vaccinations for signs of immunogenicity and reactogenicity.
Geometric mean concentrations (GMC), indicators of immune response, although higher before immunization in the seropositive group of infants, were slightly lower than in the initially seronegative group in the months following vaccination (seropositive infants; n=1165, 460, 508, and 167 vs. seronegative infants; n=93, 518, 1656, and 786). ...
Source: HighBeam Research, Hepatitis A Vaccine Proves Effective in Primed Infants of...