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Engineered HIV Requires Antibiotic to Replicate.(Brief Article)
2001 JAN 24 - (NewsRx.com & NewsRx.net) -- Researchers at the University of Amsterdam, The Netherlands, have genetically engineered a live-attenuated human immunodeficiency virus (HIV) that will only reproduce in the presence of the antibiotic doxycycline.
Their research, which may help in the development of a safe, live HIV vaccine appears in the January 2001 issue of the Journal of Virology (Verhoef et al., "Strict control of human immunodeficiency virus type 1 replication by a genetic switch: Tet for tat," Journal of Virol, 2001;75:979-987).
The designer virus (HIV-rtTA) was created in response to concerns about current live HIV vaccines. The genetic instability of current candidate vaccine viruses suggests the possibility that they could convert to once again cause disease.
To improve the safety of HIV candidate vaccines, the researchers ...
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