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Caveolin-1 Gene Transfer May Be Able to Reverse Cell Transformation.(Brief Article)
2001 JAN 24 - (NewsRx.com & NewsRx.net) -- Researchers in New York have shown that the transfer of caveolin-1 DNA to cells derived from squamous cell carcinomas can halt the growth of the malignant cells, a finding that may lead to the development of new strategies for managing cervical cancer.
"Squamous cell carcinomas of the lung and cervix arise by neoplastic transformation of their respective tissue epithelia," M.P. Lisanti and colleagues at the Albert Einstein College of Medicine explained in the journal Biochemistry. "In the case of cervical carcinomas, an increasing body of evidence implicates the human papillomavirus, HPV (types 16 and Is), as playing a pivotal role in this malignant transformation process."
In their investigation of this process, Lisanti et al. found that the viral oncoprotein E6, in addition to blocking the actions of the tumor suppressor gene p53, also downregulates the expression of the tumor suppressor protein caveolin-1 ("Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation," Biochemistry-USA, 2000;39(45):13916-13924).
The researchers evaluated the results of using an adenovirus vector to transfer caveolin-1 cDNA into SiHa cells, a cell line derived from malignant cervical squamous cells. SiHa cells contain a complete copy of the HPV 16 genome, and have extremely low levels of caveolin-1 expression due to the presence of E6.
They found that, ...
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Source: HighBeam Research, Caveolin-1 Gene Transfer May Be Able to Reverse Cell...