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Model Suggests Treatment During Antepartum Stage of Pregnancy is Best Strategy.(tuberculosis )
2001 JAN 11 - (NewsRx.com) --- by Sonia Bell-Nichols, staff medical writer -- The best strategy for protecting women with latent tuberculosis infections during pregnancy is to treat them during the antepartum period, according to research published in Obstetrics and Gynecology.
Latent tuberculosis is defined as having a positive skin test but a negative chest image on radiographic examination. Researchers at the University of North Carolina used a Markov decision-analysis model to determine the best way to treat latent tuberculosis in pregnant women.
The model incorporated three treatment choices for purposes of decision-making: provide no treatment, provide treatment beginning at the 20th week of pregnancy for six months, or provide treatment following delivery for six months. In both treatment scenarios, isoniazid and pyridoxine therapy would be the treatment method.
"Under base-case assumptions, the fewest cases of tuberculosis within the cohort occurred with antepartum treatment (1,400 per 100,000) compared with no treatment (3,300 per 100,000) or postpartum treatment (1,800 per 100,000)," reported lead author Kim A. Boggess and associates. Boggess is a faculty member in UNC's department of Obstetrics and Gynecology.
Even though some cases of isoniazid-related hepatitis or death would be ...
- Model Suggests Treatment During Antepartum Stage of Pregnancy is Best Strategy.
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