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2001 JAN 11 - (NewsRx.com) -- Women infected with human papillomavirus (HPV) who develop cervical cancer may be genetically predisposed to its development.
Certain strains of HPV are known to be associated with cervical cancer, but not all women infected with such strains develop malignancy. In fact, according to U.B. Gyllensten, of the University Uppsala, in Sweden, and colleagues, most infected women don't develop cervical cancer. Why is that?
"Our results indicate development of cervical tumors depends, to a significant extent, on inherited genetic factors. Genetic predisposing factors may influence the likelihood of, sensitivity to, or persistence of HPV infection, as well as the rate of tumor development," the researchers reported in the December 1, 2000, issue of the International Journal of Cancer.
Gyllensten et al. studied biological and adoptive mothers, and full, half-, and adoptive sisters of women with cervical cancer to determine their genetic predisposal to the disease, as well as any environmental liability (Heritability of cervical tumors," ...
Source: HighBeam Research, Genetics Play Role in Development of Cervical Cancer.