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Endothelin-1 and Endothelin-A Receptor: Targets for Cancer Therapy?
2001 JAN 11 - (NewsRx.com) -- Endothelin-1 (ET-1) induces the growth of human papillomavirus (HPV) cells, which express endothelin-A receptors (ETAR). Thus, these receptors may be appropriate targets for anticancer therapy, researchers suggest.
HPV is known to be associated with cervical cancer. HPV keratinocytes release ET-1, which causes an increased growth response of HPV cell lines. In a study published in the FASEB Journal, researchers presented results of an investigation of ET-1 and its role in cervical carcinoma.
"These results demonstrate that ET- 1 participates in the progression of neoplastic growth in HP V-associated carcinoma in which ETAR are increased and could be targeted for antitumor therapy," reported A. Venuti, of the Regina Elena Cancer Institute, in Italy, and associates.
Venuti et al. studied several HPV lines, all of which released ET-1 and mRNA for ET-1. The viral cell lines also expressed a large number of ETAR, they said. Non-HPV cell lines did not secrete ET-l, but did release endothelin-B receptor (ETBR) mRNA ("Expression of endothelin-1 and endothelin-A receptor in HP ...
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